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ATXN7L2 Produkte

(Ataxin 7-Like 2 (ATXN7L2))

Kategorien

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].

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Ausgewählte ATXN7L2 Kategorien

ATXN7L2 Antikörper

High quality antibodies with extensive validation data.

Empfohlene ATXN7L2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, FACS
Validierungen
  • (2)
Kat. Nr. ABIN655240
Menge 400 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6258382
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Bat, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Applikation WB
Validierungen
  • (1)
Kat. Nr. ABIN6743251
Menge 100 μL
Datenblatt Datenblatt

Empfohlene ATXN7L2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr. ABIN3089587
Menge 1 mg
Datenblatt Datenblatt

Synonyme und alternative Namen zu ATXN7L2

ataxin 7-like 2 (Atxn7l2), ataxin 7 like 2 (ATXN7L2), ataxin 7-like 2b (atxn7l2b), ataxin 7-like 2a (atxn7l2a), ataxin 7 like 2 (Atxn7l2), 2610528J18Rik, atxn7l2, RGD1307047, wu:fi32b11, wu:fi36e12, zgc:92454, zgc:136546

Bezeichner auf Proteinebene für ATXN7L2

  • ataxin-7-like protein 2
  • mFLJ00381 protein
  • ataxin 7-like 1
  • ataxin 7-like 2
  • fi32b11
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