BACE1 Produkte
(Beta-secretase 1 (BACE1))
Kategorien
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011].
antibodies-online.com steht für hochwertige Forschungsprodukte. Suchen, finden und bestellen Sie Tools mit umfangreichen Validierungsdaten, Bildern, Referenzen. Unser wissenschaftlicher Kundenservice steht Ihnen jederzeit zur Verfügung, wenn Sie Fragen zur Auswahl oder Anwendung unserer Produkte haben.
Ausgewählte BACE1 Kategorien
BACE1 Antikörper
High quality antibodies with extensive validation data.
BACE1 ELISA Kits
Reliable ELISA kits for a wide range of species.
BACE1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene BACE1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC (p), PLA
Validierungen
- (6)
Kat. Nr.
ABIN2566113
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, ICC, FACS
Validierungen
- (6)
Kat. Nr.
ABIN2682977
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Applikation
WB, IHC, IF
Validierungen
- (6)
Kat. Nr.
ABIN2782766
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene BACE1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6954088
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6963107
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6965161
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene BACE1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (2)
Kat. Nr.
ABIN7273905
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (2)
Kat. Nr.
ABIN7273904
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
HEK-293 Cells
Validierungen
- (2)
Kat. Nr.
ABIN7273906
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren BACE1 Produkten
: "Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration." in: Nature communications, Vol. 13, Issue 1, pp. 5308, (2022) (PubMed).: "Extracellular vesicles: where the amyloid precursor protein carboxyl-terminal fragments accumulate and amyloid-β oligomerizes." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 34, Issue 9, pp. 12922-12931, (2021) (PubMed).
: "A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients." in: Neurobiology of aging, Vol. 84, pp. 26-32, (2020) (PubMed).
: "Inhibition of BACE1, the β-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus." in: Neural regeneration research, Vol. 15, Issue 8, pp. 1546-1553, (2020) (PubMed).
: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." in: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, (2018) (PubMed).
: "Comparative study of the effects of phosphatidylcholine rich in DHA and EPA on Alzheimer's disease and the possible mechanisms in CHO-APP/PS1 cells and SAMP8 mice." in: Food & function, Vol. 9, Issue 1, pp. 643-654, (2018) (PubMed).
: "Thymoquinone-rich fraction nanoemulsion (TQRFNE) decreases Aβ40 and Aβ42 levels by modulating APP processing, up-regulating IDE and LRP1, and down-regulating BACE1 and RAGE in response to high ..." in: Biomedicine & pharmacotherapy, Vol. 95, pp. 780-788, (2018) (PubMed).
: "An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity." in: PLoS ONE, Vol. 11, Issue 11, pp. e0166415, (2017) (PubMed).
: "Dopamine D2 receptor and β-arrestin 2 mediate Amyloid-β elevation induced by anti-parkinson's disease drugs, levodopa and piribedil, in neuronal cells." in: PLoS ONE, Vol. 12, Issue 3, pp. e0173240, (2017) (PubMed).
: "Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus." in: Neurochemical research, Vol. 41, Issue 5, pp. 1192-9, (2016) (PubMed).
Synonyme und alternative Namen zu BACE1
beta-secretase 1 (BACE1), beta-site APP cleaving enzyme 1 (Bace1), beta-secretase 1 (Bace1), beta-site APP-cleaving enzyme 1 (bace1), ASP2, BACE, Bace, BACE1, C76936, HSPC104, MGC145931, zgc:77409Bezeichner auf Proteinebene für BACE1
- APP beta-secretase
- asp 2
- aspartyl protease 2
- beta-secretase 1
- beta-secretase 1 precursor variant 1
- beta-site APP cleaving enzyme 1
- beta-site amyloid beta A4 precursor protein-cleaving enzyme
- memapsin-2
- membrane-associated aspartic protease 2
- transmembrane aspartic proteinase Asp2
- ASP2
- beta-site amyloid precursor protein cleaving enzyme 1
- beta-site APP cleaving enzyme
- beta secretase 1
- beta-secretase 1 isoform A preproprotein
- beta-secretase 1 isoform B preproprotein
- beta-secretase 1 isoform C preproprotein
- beta-site APP-cleaving enzyme 1
- beta-secretase 1-like
Sie sind hier:
