BCCIP Produkte
(BRCA2 and CDKN1A Interacting Protein (BCCIP))
Kategorien
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte BCCIP Kategorien
BCCIP Antikörper
High quality antibodies with extensive validation data.
BCCIP ELISA Kits
Reliable ELISA kits for a wide range of species.
BCCIP Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene BCCIP Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IF, IHC (p), ICC
Validierungen
- (4)
Kat. Nr.
ABIN2856892
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC
Validierungen
- (4)
Kat. Nr.
ABIN6137485
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (3)
Kat. Nr.
ABIN527937
Menge
50 μg
Datenblatt
Datenblatt
Empfohlene BCCIP ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6730078
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1124123
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Cow
Analytical Method
Validierungen
Kat. Nr.
ABIN1124121
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene BCCIP Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7122031
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1346518
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1346520
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren BCCIP Produkten
: "The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair." in: Molecular and cellular biology, Vol. 25, Issue 5, pp. 1949-57, (2005) (PubMed).: "Inhibition of G1 to S cell cycle progression by BCCIP beta." in: Cell cycle (Georgetown, Tex.), Vol. 3, Issue 3, pp. 343-8, (2004) (PubMed).
: "Unique de novo mutation of BRCA2 in a woman with early onset breast cancer." in: Journal of medical genetics, Vol. 39, Issue 2, pp. 126-8, (2002) (PubMed).
: "Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2." in: Oncogene, Vol. 20, Issue 3, pp. 336-45, (2001) (PubMed).
: "TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase." in: The Journal of biological chemistry, Vol. 275, Issue 40, pp. 31145-54, (2000) (PubMed).
Synonyme und alternative Namen zu BCCIP
BRCA2 and CDKN1A interacting protein (BCCIP), BRCA2 and CDKN1A interacting protein (bccip), BRCA2 and CDKN1A interacting protein L homeolog (bccip.L), BRCA2 and CDKN1A interacting protein (Bccip), 1110013J05Rik, BCCIP, DKFZp459K2416, MGC82792, MGC89311, mp:zf637-1-000774, tok-1, TOK-1, TOK1, zgc:110272Bezeichner auf Proteinebene für BCCIP
- BRCA2 and CDKN1A interacting protein
- protein BCCIP homolog
- BRCA2 and CDKN1A-interacting protein
- bccip-like
- BCCIPalpha
- BCCIPbeta
- BRCA2 and Cip1/p21 interacting protein
- TOK-1alpha
- TOK-1beta
- cdk inhibitor p21 binding protein
- p21- and CDK-associated protein 1
- protein TOK-1
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