BIM Produkte
(BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
Kategorien
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jul 2008].
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Ausgewählte BIM Kategorien
BIM Antikörper
High quality antibodies with extensive validation data.
BIM ELISA Kits
Reliable ELISA kits for a wide range of species.
BIM Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene BIM Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, ICC, IP
Validierungen
- (8)
Kat. Nr.
ABIN7430234
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p), FACS
Validierungen
- (4)
Kat. Nr.
ABIN652493
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
IHC, ELISA, IF
Validierungen
- (3)
Kat. Nr.
ABIN7145302
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene BIM ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6965138
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6954063
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380955
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene BIM Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1346560
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1346562
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1346558
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren BIM Produkten
: "Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling." in: Cell death and differentiation, Vol. 24, Issue 1, pp. 111-119, (2018) (PubMed).: "Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells." in: Biochemical and biophysical research communications, Vol. 480, Issue 3, pp. 387-393, (2017) (PubMed).
: "RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy." in: Autophagy, Vol. 11, Issue 7, pp. 975-94, (2015) (PubMed).
: "Apoptosis induced by Ginkgo biloba (EGb761) in melanoma cells is Mcl-1-dependent." in: PLoS ONE, Vol. 10, Issue 4, pp. e0124812, (2015) (PubMed).
: "B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins." in: The Journal of biological chemistry, Vol. 289, Issue 38, pp. 26481-91, (2014) (PubMed).
: "Valproic acid protects motor neuron death by inhibiting oxidative stress and endoplasmic reticulum stress-mediated cytochrome C release after spinal cord injury." in: Journal of neurotrauma, Vol. 31, Issue 6, pp. 582-94, (2014) (PubMed).
: "Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer." in: The Journal of biological chemistry, Vol. 288, Issue 1, pp. 368-81, (2013) (PubMed).
: "OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis." in: PLoS ONE, Vol. 8, Issue 12, pp. e84073, (2013) (PubMed).
: "Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress." in: Cell death & disease, Vol. 3, pp. e337, (2012) (PubMed).
: "Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription." in: Oncogene, Vol. 30, Issue 22, pp. 2534-46, (2011) (PubMed).
Synonyme und alternative Namen zu BIM
BCL2-like 11 (bcl2l11), BCL2 like 11 (BCL2L11), BCL2-like 11 (apoptosis facilitator) (Bcl2l11), BCL2 like 11 (Bcl2l11), 1500006F24Rik, BAM, bim, BIM, Bim, BIMEL, BimL, BOD, BodBezeichner auf Proteinebene für BIM
- BCL2-like 11
- Bcl-2 interacting mediator of cell death
- bcl-2 interacting mediator of cell death
- bcl-2 interacting protein Bim
- bcl-2-like protein 11
- bcl-2-related ovarian death agonist
- Bcl2 interacting mediator of cell death
- bcl2-L-11
- bcl2-interacting mediator of cell death
- Bcl-2 related apoptotic gene product BimL
- bcl-2-related ovarian death protein
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