BPTF Produkte
(Bromodomain PHD Finger Transcription Factor (BPTF))
Kategorien
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008].
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Ausgewählte BPTF Kategorien
BPTF Antikörper
High quality antibodies with extensive validation data.
Empfohlene BPTF Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
IHC, IF
Validierungen
- (6)
Kat. Nr.
ABIN7073234
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Mouse, Rat
Applikation
WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro), ICC
Validierungen
- (3)
Kat. Nr.
ABIN1386560
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA
Validierungen
- (2)
- (2)
Kat. Nr.
ABIN968990
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene BPTF Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7122052
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (2)
Kat. Nr.
ABIN2669695
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren BPTF Produkten
: "Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes." in: eLife, Vol. 8, (2019) (PubMed).: "Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z." in: The Journal of biological chemistry, Vol. 285, Issue 7, pp. 4645-51, (2010) (PubMed).
: "BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9804-13, (2009) (PubMed).
: "B-cell linker protein prevents aneuploidy by inhibiting cytokinesis." in: Cancer science, Vol. 99, Issue 12, pp. 2444-54, (2008) (PubMed).
: "Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells." in: PLoS genetics, Vol. 4, Issue 10, pp. e1000241, (2008) (PubMed).
: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, (2008) (PubMed).
Synonyme und alternative Namen zu BPTF
bromodomain PHD finger transcription factor (BPTF), bromodomain PHD finger transcription factor (Bptf), nucleosome-remodeling factor subunit NURF301 (LOC5576547), fetal alzheimer antigen, falz (CpipJ_CPIJ011285), bromodomain PHD finger transcription factor (bptf), 9430093H17Rik, BPTF, FAC1, FALZ, Falz, NURF301Bezeichner auf Proteinebene für BPTF
- bromodomain and PHD domain transcription factor
- bromodomain and PHD finger-containing transcription factor
- fetal Alz-50 clone 1 protein
- fetal Alz-50 reactive clone 1
- fetal Alzheimer antigen
- nucleosome remodeling factor, large subunit
- nucleosome-remodeling factor subunit BPTF
- fetal alzheimer antigen, falz
- bromodomain PHD finger transcription factor
- nucleosome-remodeling factor subunit BPTF-like
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