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BRD4 Produkte

(Bromodomain Containing 4 (BRD4))

Kategorien

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15\;19)(q13\;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].

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Ausgewählte BRD4 Kategorien

BRD4 Antikörper

High quality antibodies with extensive validation data.

BRD4 ELISA Kits

Reliable ELISA kits for a wide range of species.

BRD4 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene BRD4 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Mouse, Rat
Applikation IHC, IF
Validierungen
  • (4)
Kat. Nr. ABIN7010051
Menge 60 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC
Validierungen
  • (4)
Kat. Nr. ABIN6137653
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, ELISA, IHC, IF, ICC
Validierungen
  • (4)
Kat. Nr. ABIN6260309
Menge 100 μL
Datenblatt Datenblatt

Empfohlene BRD4 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6965241
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6954198
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method
Validierungen
Kat. Nr. ABIN1124204
Menge 96 tests
Datenblatt Datenblatt

Empfohlene BRD4 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN7122050
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN7319875
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (1)
Kat. Nr. ABIN6964231
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren BRD4 Produkten

Yamada, Honma, Mochizuki, Goda: "BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver." in: Metabolism: clinical and experimental, Vol. 65, Issue 10, pp. 1478-88, (2017) (PubMed).

Surface, Fields, Subramanian, Behmer, Udeshi, Peach, Carr, Jaffe, Boyer: "H2A.Z.1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs." in: Cell reports, Vol. 14, Issue 5, pp. 1142-55, (2016) (PubMed).

Zimmermann, Aguilera, Castellucci, Rossato, Costa, Lunardi, Ostuni, Girolomoni, Natoli, Bazzoni, Tamassia, Cassatella: "Chromatin remodelling and autocrine TNFα are required for optimal interleukin-6 expression in activated human neutrophils." in: Nature communications, Vol. 6, pp. 6061, (2015) (PubMed).

Alekseyenko, Walsh, Wang, Grayson, Hsi, Kharchenko, Kuroda, French: "The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains." in: Genes & development, Vol. 29, Issue 14, pp. 1507-23, (2015) (PubMed).

Flajollet, Rachez, Ploton, Schulz, Gallais, Métivier, Pawlak, Leray, Issulahi, Héliot, Staels, Salbert, Lefebvre: "The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors." in: PLoS ONE, Vol. 8, Issue 6, pp. e64880, (2013) (PubMed).

Rahman, Sowa, Ottinger, Smith, Shi, Harper, Howley: "The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3." in: Molecular and cellular biology, Vol. 31, Issue 13, pp. 2641-52, (2011) (PubMed).

Zuber, Shi, Wang, Rappaport, Herrmann, Sison, Magoon, Qi, Blatt, Wunderlich, Taylor, Johns, Chicas, Mulloy, Kogan, Brown, Valent, Bradner, Lowe, Vakoc: "RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia." in: Nature, Vol. 478, Issue 7370, pp. 524-8, (2011) (PubMed).

Mertz, Conery, Bryant, Sandy, Balasubramanian, Mele, Bergeron, Sims: "Targeting MYC dependence in cancer by inhibiting BET bromodomains." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 40, pp. 16669-74, (2011) (PubMed).

Powell, Smith, Sowa, Harper, Iftner, Stubenrauch, Howley: "NCoR1 mediates papillomavirus E8;E2C transcriptional repression." in: Journal of virology, Vol. 84, Issue 9, pp. 4451-60, (2010) (PubMed).

Gagnon, Joubert, Sénéchal, Fradet-Turcotte, Torre, Archambault: "Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4." in: Journal of virology, Vol. 83, Issue 9, pp. 4127-39, (2009) (PubMed).

Synonyme und alternative Namen zu BRD4

bromodomain containing 4 L homeolog (brd4.L), bromodomain containing 4 (BRD4), bromodomain containing 4 (brd4), bromodomain-containing protein 4 (LOC100409351), bromodomain containing 4 (Brd4), BRD4, brd4-b, Brd5, CAP, fb18g03, HUNK1, HUNKI, MCAP, WI-11513, wu:fb18g03

Bezeichner auf Proteinebene für BRD4

  • Bromodomain-containing protein 4B
  • bromodomain-containing protein 4B
  • bromodomain containing 4
  • bromodomain-containing protein 4
  • bromodomain 4
  • bromodomain-containing protein 4-like
  • bromodomain containing protein 4
  • bromodomain-containing 4
  • chromosome-associated protein
  • bromodomain-containing 5
  • fsh-like protein
  • mitotic chromosome-associated protein
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