BRSK1 Produkte
(BR Serine/threonine Kinase 1 (BRSK1))
Kategorien
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV- induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.
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Ausgewählte BRSK1 Kategorien
BRSK1 Antikörper
High quality antibodies with extensive validation data.
BRSK1 ELISA Kits
Reliable ELISA kits for a wide range of species.
BRSK1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene BRSK1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC
Validierungen
- (3)
Kat. Nr.
ABIN7169019
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p)
Validierungen
- (2)
Kat. Nr.
ABIN652432
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB
Validierungen
- (3)
- (1)
Kat. Nr.
ABIN1881121
Menge
400 μL
Datenblatt
Datenblatt
Empfohlene BRSK1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN5648007
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Validierungen
Kat. Nr.
ABIN1157191
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene BRSK1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1346887
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Insect Cells
Validierungen
Kat. Nr.
ABIN5509205
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3090446
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren BRSK1 Produkten
: "Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 36, pp. 11938-50, (2010) (PubMed).: "SADB phosphorylation of gamma-tubulin regulates centrosome duplication." in: Nature cell biology, Vol. 11, Issue 9, pp. 1081-92, (2009) (PubMed).
: "C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest." in: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 77-84, (2008) (PubMed).
: "Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation." in: The Journal of biological chemistry, Vol. 283, Issue 22, pp. 14946-54, (2008) (PubMed).
: "Mammalian SAD kinases are required for neuronal polarization." in: Science (New York, N.Y.), Vol. 307, Issue 5711, pp. 929-32, (2005) (PubMed).
: "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function." in: The Journal of biological chemistry, Vol. 279, Issue 30, pp. 31164-70, (2004) (PubMed).
: "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1." in: The EMBO journal, Vol. 23, Issue 4, pp. 833-43, (2004) (PubMed).
Synonyme und alternative Namen zu BRSK1
BR serine/threonine kinase 1 (BRSK1), BR serine/threonine kinase 1 (Brsk1), BRSK1, Gm1100, hSAD1, RGD1563268, SAD-B, Sad-b, SADBBezeichner auf Proteinebene für BRSK1
- BR serine/threonine kinase 1
- BR serine/threonine-protein kinase 1-like
- BR serine/threonine-protein kinase 1
- SAD1 homolog
- SAD1 kinase
- SadB kinase short isoform
- brain-selective kinase 1
- brain-specific serine/threonine-protein kinase 1
- protein kinase SAD1A
- serine/threonine-protein kinase BRSK1
- serine/threonine-protein kinase SAD-B
- synapses of Amphids Defective homolog 1
- serine/threonine kinase SAD-B
- serine/threonine kinase SADB
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