BTBD12 Produkte
(BTB (POZ) Domain Containing 12 (BTBD12))
Kategorien
This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011].
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Ausgewählte BTBD12 Kategorien
BTBD12 Antikörper
High quality antibodies with extensive validation data.
Empfohlene BTBD12 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN529697
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human, Monkey
Applikation
WB
Validierungen
- (1)
Kat. Nr.
ABIN6746693
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
IP, IHC (p), IHC, IF
Validierungen
- (1)
Kat. Nr.
ABIN2571811
Menge
50 μL
Datenblatt
Datenblatt
Empfohlene BTBD12 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Schizosaccharomyces pombe
Source
Yeast
Validierungen
Kat. Nr.
ABIN1652594
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren BTBD12 Produkten
: "Expression of Telomere-Associated Proteins is Interdependent to Stabilize Native Telomere Structure and Telomere Dysfunction by G-Quadruplex Ligand Causes TERRA Upregulation." in: Cell biochemistry and biophysics, (2017) (PubMed).: "Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment." in: mBio, Vol. 7, Issue 5, (2016) (PubMed).
: "SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres." in: Cell reports, Vol. 4, Issue 5, pp. 861-9, (2013) (PubMed).
: "The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP/SLX4." in: Human molecular genetics, Vol. 21, Issue 22, pp. 4948-56, (2012) (PubMed).
: "Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis." in: PLoS genetics, Vol. 7, Issue 6, pp. e1002094, (2011) (PubMed).
: "Mutations of the SLX4 gene in Fanconi anemia." in: Nature genetics, Vol. 43, Issue 2, pp. 142-6, (2011) (PubMed).
Synonyme und alternative Namen zu BTBD12
SLX4 structure-specific endonuclease subunit (Slx4), SLX4 structure-specific endonuclease subunit (SLX4), SLX4 structure-specific endonuclease subunit homolog (SLX4), SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) (Slx4), AI256635, AI426760, Btbd12, BTBD12, D16Bwg1016e, FANCP, MUS312, RGD1566009Bezeichner auf Proteinebene für BTBD12
- BTB (POZ) domain containing 12
- SLX4 structure-specific endonuclease subunit homolog
- structure-specific endonuclease subunit SLX4
- BTB/POZ domain-containing protein 12
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