CACNB4 Produkte
(Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))
Kategorien
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
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Ausgewählte CACNB4 Kategorien
CACNB4 Antikörper
High quality antibodies with extensive validation data.
CACNB4 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene CACNB4 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IF, ICC, IHC (p)
Validierungen
- (4)
Kat. Nr.
ABIN2854649
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Applikation
WB
Validierungen
- (4)
Kat. Nr.
ABIN2774681
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC, IF
Validierungen
- (2)
Kat. Nr.
ABIN7175600
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene CACNB4 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6213229
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene CACNB4 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1347838
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1347836
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3090330
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren CACNB4 Produkten
: "Nerve injury induces a Gem-GTPase-dependent downregulation of P/Q-type Ca2+ channels contributing to neurite plasticity in dorsal root ganglion neurons." in: Pflügers Archiv : European journal of physiology, Vol. 467, Issue 2, pp. 351-66, (2015) (PubMed).: "Differential neuronal targeting of a new and two known calcium channel ?4 subunit splice variants correlates with their regulation of gene expression." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 4, pp. 1446-61, (2014) (PubMed).
: "The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 37, pp. 12289-303, (2014) (PubMed).
: "CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-? plaques in an Alzheimer's disease mouse model." in: Journal of Alzheimer's disease : JAD, Vol. 37, Issue 2, pp. 439-51, (2013) (PubMed).
: "Up-regulation of Cav?3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain." in: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 6002-13, (2012) (PubMed).
: "Regional expression and subcellular localization of the voltage-gated calcium channel ? subunits in the developing mouse brain." in: Journal of neurochemistry, Vol. 122, Issue 6, pp. 1095-107, (2012) (PubMed).
: "RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction." in: Cell, Vol. 144, Issue 2, pp. 282-95, (2011) (PubMed).
: "CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation." in: Journal of neurochemistry, Vol. 112, Issue 1, pp. 150-61, (2010) (PubMed).
: "Reciprocal interactions regulate targeting of calcium channel beta subunits and membrane expression of alpha1 subunits in cultured hippocampal neurons." in: The Journal of biological chemistry, Vol. 285, Issue 8, pp. 5776-91, (2010) (PubMed).
: "Differential modulation of N-type calcium channels by micro-opioid receptors in oxytocinergic versus vasopressinergic neurohypophysial terminals." in: Journal of cellular physiology, Vol. 225, Issue 1, pp. 276-88, (2010) (PubMed).
Synonyme und alternative Namen zu CACNB4
calcium voltage-gated channel auxiliary subunit beta 4 (CACNB4), calcium channel, voltage-dependent, beta 4 subunit (Cacnb4), calcium voltage-gated channel auxiliary subunit beta 4 (Cacnb4), calcium channel, voltage-dependent, beta 4 subunit (cacnb4.1), calcium channel, voltage-dependent, beta 4 subunit (cacnb4), calcium channel, voltage-dependent, beta 4a subunit (cacnb4a), 3110038O15Rik, CAB4, CACNB4, cacnb4.2, CACNLB4, Cchb4, EA5, EIG9, EJM, EJM4, EJM6, lethargic, lhBezeichner auf Proteinebene für CACNB4
- calcium channel voltage-dependent subunit beta 4
- dihydropyridine-sensitive L-type, calcium channel beta-4 subunit
- voltage-dependent L-type calcium channel subunit beta-4
- CAB4
- calcium channel beta 4 subunit
- voltage-dependent calcium channel beta 4 subunit
- calcium channel, voltage-dependent, beta 4 subunit
- voltage-gated calcium channel beta 4.1 subunit
- voltage-dependent L-type calcium channel subunit beta-4-like
- CAB4a
- voltage-dependent calcium channel beta 4a subunit
- voltage-gated calcium channel beta-4.2
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