CARD8 Produkte
(Caspase Recruitment Domain Family, Member 8 (CARD8))
Kategorien
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010].
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Ausgewählte CARD8 Kategorien
CARD8 Antikörper
High quality antibodies with extensive validation data.
CARD8 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene CARD8 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ICC, IP, FACS, DB
Validierungen
- (3)
Kat. Nr.
ABIN930979
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
IHC, ELISA
Validierungen
- (2)
Kat. Nr.
ABIN7146923
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IP
Validierungen
- (2)
Kat. Nr.
ABIN524838
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene CARD8 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6202321
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene CARD8 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1348061
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1348057
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1348059
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren CARD8 Produkten
: "Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease." in: The Journal of clinical investigation, Vol. 128, Issue 5, pp. 1793-1806, (2018) (PubMed).: "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13952-8, (2002) (PubMed).
: "TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation." in: FEBS letters, Vol. 521, Issue 1-3, pp. 165-9, (2002) (PubMed).
: "TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer." in: The Journal of biological chemistry, Vol. 276, Issue 34, pp. 32220-9, (2001) (PubMed).
: "DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis." in: The Journal of cell biology, Vol. 151, Issue 3, pp. 495-506, (2000) (PubMed).
: "TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)." in: Immunity, Vol. 6, Issue 1, pp. 79-88, (1997) (PubMed).
: "LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 9, pp. 4615-9, (1997) (PubMed).
Synonyme und alternative Namen zu CARD8
caspase recruitment domain family, member 8 (CARD8), caspase recruitment domain-containing protein 8 (LOC718594), caspase recruitment domain family member 8 (CARD8), CARD8, CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCANBezeichner auf Proteinebene für CARD8
- caspase recruitment domain family, member 8
- CARD inhibitor of NF-kappaB-activating ligands
- apoptotic protein NDPP1
- caspase recruitment domain-containing protein 8
- tumor up-regulated CARD-containing antagonist of CASP9
- tumor up-regulated CARD-containing antagonist of caspase nine
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