CBL Produkte
(Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
Kategorien
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012].
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Ausgewählte CBL Kategorien
CBL Antikörper
High quality antibodies with extensive validation data.
CBL ELISA Kits
Reliable ELISA kits for a wide range of species.
CBL Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene CBL Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IHC, ICC, FACS
Validierungen
- (3)
- (7)
Kat. Nr.
ABIN968993
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IP
Validierungen
- (5)
Kat. Nr.
ABIN560198
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IP
Validierungen
- (4)
Kat. Nr.
ABIN949994
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene CBL ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380198
Menge
2 x 96 tests
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380199
Menge
2 x 96 tests
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380200
Menge
2 x 96 tests
Datenblatt
Datenblatt
Empfohlene CBL Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1348168
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1348170
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7417087
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren CBL Produkten
: "c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cells." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 27008-18, (2010) (PubMed).: "Cbl negatively regulates JNK activation and cell death." in: Cell research, Vol. 19, Issue 8, pp. 950-61, (2009) (PubMed).
: "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. ..." in: Nature, Vol. 460, Issue 7257, pp. 904-8, (2009) (PubMed).
: "Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. ..." in: Blood, Vol. 114, Issue 9, pp. 1859-63, (2009) (PubMed).
: "The Cbl family proteins: ring leaders in regulation of cell signaling." in: Journal of cellular physiology, Vol. 209, Issue 1, pp. 21-43, (2006) (PubMed).
: "c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses." in: The Biochemical journal, Vol. 391, Issue Pt 2, pp. 153-66, (2005) (PubMed).
: "Grb2 regulates internalization of EGF receptors through clathrin-coated pits." in: Molecular biology of the cell, Vol. 14, Issue 3, pp. 858-70, (2003) (PubMed).
: "Cbl-mediated ubiquitinylation and negative regulation of Vav." in: The Journal of biological chemistry, Vol. 278, Issue 40, pp. 38495-504, (2003) (PubMed).
: "Cbl: many adaptations to regulate protein tyrosine kinases." in: Nature reviews. Molecular cell biology, Vol. 2, Issue 4, pp. 294-307, (2001) (PubMed).
: "Beyond the RING: CBL proteins as multivalent adapters." in: Oncogene, Vol. 20, Issue 44, pp. 6382-402, (2001) (PubMed).
Synonyme und alternative Namen zu CBL
Casitas B-lineage lymphoma (Cbl), Cbl proto-oncogene (CBL), Cbl proto-oncogene (Cbl), 4732447J05Rik, c-Cbl, C-CBL, c-cbl-like, cbl, Cbl-2, CBL2, FRA11B, NSLL, RGD1561386, RNF55Bezeichner auf Proteinebene für CBL
- E3 ubiquitin-protein ligase CBL
- casitas B-lineage lymphoma proto-oncogene
- proto-oncogene c-CBL
- signal transduction protein CBL
- Cas-Br-M (murine) ecotropic retroviral transforming sequence
- RING finger protein 55
- fragile site, folic acid type, rare, fra(11)(q23.3)
- oncogene CBL2
- proto-oncogene c-Cbl
- Casitas B-lineage lymphoma
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