Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Produkte
(Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB))
Kategorien
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {ECO:0000269|PubMed:10646608, ECO:0000269|PubMed:10646609, ECO:0000269|PubMed:11070165, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:12771181, ECO:0000269|PubMed:15308098}.
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Ausgewählte Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Kategorien
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Antikörper
High quality antibodies with extensive validation data.
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase ELISA Kits
Reliable ELISA kits for a wide range of species.
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Applikation
WB, FACS, IHC (p)
Validierungen
- (3)
Kat. Nr.
ABIN652612
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validierungen
- (2)
Kat. Nr.
ABIN760256
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IHC
Validierungen
- (2)
Kat. Nr.
ABIN6260515
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6965529
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1131076
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6200984
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN1348172
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7122186
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1348174
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Produkten
: "Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b)." in: The Journal of biological chemistry, Vol. 290, Issue 42, pp. 25595-608, (2015) (PubMed).: "Cbl-b mediates TGF? sensitivity by downregulating inhibitory SMAD7 in primary T cells." in: Journal of molecular cell biology, Vol. 5, Issue 6, pp. 358-68, (2013) (PubMed).
: "The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 14, pp. 6459-64, (2010) (PubMed).
Synonyme und alternative Namen zu Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase
Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog (cblb.S), Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog (cblb.L), Casitas B-lineage lymphoma b (Cblb), Cbl proto-oncogene B (Cblb), Cbl proto-oncogene B (CBLB), AI429560, AI851073, Cbl-b, cblb, rnf56Bezeichner auf Proteinebene für Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase
- Cas-Br-M (murine) ecotropic retroviral transforming sequence b
- Cbl proto-oncogene, E3 ubiquitin protein ligase B
- E3 ubiquitin-protein ligase CBL-B-B
- SH3-binding protein CBL-B-B
- signal transduction protein CBL-B-B
- E3 ubiquitin-protein ligase CBL-B-A
- SH3-binding protein CBL-B-A
- signal transduction protein CBL-B-A
- Casitas B-lineage lymphoma proto-oncogene b
- E3 ubiquitin-protein ligase CBL-B
- RING-type E3 ubiquitin transferase CBL-B
- SH3-binding protein CBL-B
- Signal transduction protein CBL-B
- casitas B-lineage lymphoma proto-oncogene b
- signal transduction protein CBL-B
- Cas-Br-M (murine) ectropic retroviral transforming sequence b
- Casitas B-lineage lymphoma b
- Cbl proto-oncogene B, E3 ubiquitin protein ligase
- LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B
- Cas-Br-M ecotropic retroviral transforming sequence b
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