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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Produkte

(Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB))
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {ECO:0000269|PubMed:10646608, ECO:0000269|PubMed:10646609, ECO:0000269|PubMed:11070165, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:12771181, ECO:0000269|PubMed:15308098}.

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Ausgewählte Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Kategorien

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Antikörper

High quality antibodies with extensive validation data.

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase ELISA Kits

Reliable ELISA kits for a wide range of species.

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Rat
Applikation WB, FACS, IHC (p)
Validierungen
  • (3)
Kat. Nr. ABIN652612
Menge 400 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validierungen
  • (2)
Kat. Nr. ABIN760256
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, ELISA, IHC
Validierungen
  • (2)
Kat. Nr. ABIN6260515
Menge 100 μL
Datenblatt Datenblatt

Empfohlene Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6965529
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method
Validierungen
Kat. Nr. ABIN1131076
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6200984
Menge 96 tests
Datenblatt Datenblatt

Empfohlene Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN1348172
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN7122186
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1348174
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Produkten

Desai, Kharade, Parekh, Iyer, Agarwal: "Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b)." in: The Journal of biological chemistry, Vol. 290, Issue 42, pp. 25595-608, (2015) (PubMed).

Gruber, Hinterleitner, Hermann-Kleiter, Meisel, Kleiter, Wang, Viola, Pfeifhofer-Obermair, Baier: "Cbl-b mediates TGF? sensitivity by downregulating inhibitory SMAD7 in primary T cells." in: Journal of molecular cell biology, Vol. 5, Issue 6, pp. 358-68, (2013) (PubMed).

Vivanco, Rohle, Versele, Iwanami, Kuga, Oldrini, Tanaka, Dang, Kubek, Palaskas, Hsueh, Evans, Mulholland, Wolle, Rajasekaran, Rajasekaran, Liau, Cloughesy, Dikic, Brennan, Wu, Mischel, Perera et al.: "The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 14, pp. 6459-64, (2010) (PubMed).

Synonyme und alternative Namen zu Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase

Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog (cblb.S), Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog (cblb.L), Casitas B-lineage lymphoma b (Cblb), Cbl proto-oncogene B (Cblb), Cbl proto-oncogene B (CBLB), AI429560, AI851073, Cbl-b, cblb, rnf56

Bezeichner auf Proteinebene für Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase

  • Cas-Br-M (murine) ecotropic retroviral transforming sequence b
  • Cbl proto-oncogene, E3 ubiquitin protein ligase B
  • E3 ubiquitin-protein ligase CBL-B-B
  • SH3-binding protein CBL-B-B
  • signal transduction protein CBL-B-B
  • E3 ubiquitin-protein ligase CBL-B-A
  • SH3-binding protein CBL-B-A
  • signal transduction protein CBL-B-A
  • Casitas B-lineage lymphoma proto-oncogene b
  • E3 ubiquitin-protein ligase CBL-B
  • RING-type E3 ubiquitin transferase CBL-B
  • SH3-binding protein CBL-B
  • Signal transduction protein CBL-B
  • casitas B-lineage lymphoma proto-oncogene b
  • signal transduction protein CBL-B
  • Cas-Br-M (murine) ectropic retroviral transforming sequence b
  • Casitas B-lineage lymphoma b
  • Cbl proto-oncogene B, E3 ubiquitin protein ligase
  • LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B
  • Cas-Br-M ecotropic retroviral transforming sequence b
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