This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008].
CCL24
Spezies: Cynomolgus
Wirt: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).
Patel, Kreider, Li, Li, Leung, Salcedo, Nardelli, Pippalla, Gentz, Thotakura, Parmelee, Gentz, Garotta: "Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors." in: The Journal of experimental medicine, Vol. 185, Issue 7, pp. 1163-72, (1997) (PubMed).
White, Imburgia, Dul, Appelbaum, ODonnell, OShannessy, Brawner, Fornwald, Adamou, Elshourbagy, Kaiser, Foley, Schmidt, Johanson, Macphee, Moores, McNulty, Scott, Schleimer, Sarau: "Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils." in: Journal of leukocyte biology, Vol. 62, Issue 5, pp. 667-75, (1997) (PubMed).