CDT2/RAMP Produkte
(Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))
Kategorien
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).
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Ausgewählte CDT2/RAMP Kategorien
CDT2/RAMP Antikörper
High quality antibodies with extensive validation data.
CDT2/RAMP Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene CDT2/RAMP Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC
Validierungen
- (2)
Kat. Nr.
ABIN7149691
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, FACS
Validierungen
- (2)
Kat. Nr.
ABIN654926
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (2)
Kat. Nr.
ABIN949333
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene CDT2/RAMP Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3092255
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3134980
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN5505614
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren CDT2/RAMP Produkten
: "Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex." in: Molecular biology of the cell, Vol. 26, Issue 13, pp. 2426-38, (2015) (PubMed).: "Overexpression of denticleless E3 ubiquitin protein ligase homolog (DTL) is related to poor outcome in gastric carcinoma." in: Oncotarget, Vol. 6, Issue 34, pp. 36615-24, (2015) (PubMed).
: "Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung." in: Disease models & mechanisms, Vol. 8, Issue 12, pp. 1531-42, (2015) (PubMed).
: "Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase." in: Molecular cell, Vol. 49, Issue 6, pp. 1159-66, (2013) (PubMed).
: "SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation." in: The Journal of cell biology, Vol. 192, Issue 1, pp. 43-54, (2011) (PubMed).
: "Prognostic significance of miR-215 in colon cancer." in: Clinical colorectal cancer, Vol. 10, Issue 4, pp. 340-7, (2011) (PubMed).
: "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex." in: Genes & development, Vol. 22, Issue 18, pp. 2496-506, (2008) (PubMed).
Synonyme und alternative Namen zu CDT2/RAMP
denticleless E3 ubiquitin protein ligase homolog (DTL), denticleless E3 ubiquitin protein ligase (Dtl), denticleless E3 ubiquitin protein ligase homolog (Dtl), denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S), denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl), 2810047L02Rik, 5730564G15Rik, cb151, CDT2, cdt2, cdt2-a, chunp6871, DCAF2, dcaf2, L2DTL, l2dtl, RAMP, Ramp, ramp, RGD1310439, wu:fb54b02Bezeichner auf Proteinebene für CDT2/RAMP
- DDB1 and CUL4 associated factor 2
- DDB1- and CUL4-associated factor 2
- RA regulated nuclear matrix associated protein
- RA-regulated nuclear matrix-associated protein
- denticleless homolog
- denticleless protein homolog
- lethal(2) denticleless protein homolog
- retinoic acid-regulated nuclear matrix-associated protein
- Meth A ramp
- meth A retinoic acid-regulated nuclear matrix-associated protein
- retinoic-acid regulated nuclear matrix-associated protein
- denticleless protein homolog A
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