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COCH Produkte

(Cochlin (COCH))

Kategorien

The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq, Oct 2008].

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Ausgewählte COCH Kategorien

COCH Antikörper

High quality antibodies with extensive validation data.

COCH ELISA Kits

Reliable ELISA kits for a wide range of species.

COCH Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene COCH Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, FACS, IHC (p)
Validierungen
  • (3)
Kat. Nr. ABIN656833
Menge 400 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IHC
Validierungen
  • (2)
Kat. Nr. ABIN7148039
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB
Validierungen
  • (2)
Kat. Nr. ABIN655279
Menge 400 μL
Datenblatt Datenblatt

Empfohlene COCH ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6954851
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN4882435
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6386083
Menge 96 tests
Datenblatt Datenblatt

Empfohlene COCH Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1349913
Menge 25 μg
Datenblatt Datenblatt
Reaktivität Mouse
Source HEK-293 Cells
Validierungen
Kat. Nr. ABIN6253496
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
Kat. Nr. ABIN6253494
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren COCH Produkten

Jung, Yoo, Choe, Park, Lee, Lee, Noh, Kim, Kang, Lee, Yoon, Jang, Yoon, Hyun, Choi: "Cleaved Cochlin Sequesters Pseudomonas aeruginosa and Activates Innate Immunity in the Inner Ear." in: Cell host & microbe, Vol. 25, Issue 4, pp. 513-525.e6, (2019) (PubMed).

Anfosso, Bardin, Francès, Vivier, Camoin-Jau, Sampol, Dignat-George: "Activation of human endothelial cells via S-endo-1 antigen (CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125(FAK)." in: The Journal of biological chemistry, Vol. 273, Issue 41, pp. 26852-6, (1998) (PubMed).

Jean, Gershenwald, Huang, Luca, Hudson, Tainsky, Bar-Eli: "Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human melanoma cells." in: The Journal of biological chemistry, Vol. 273, Issue 26, pp. 16501-8, (1998) (PubMed).

Xie, Luca, Huang, Gutman, Reich, Johnson, Bar-Eli: "Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis." in: Cancer research, Vol. 57, Issue 11, pp. 2295-303, (1997) (PubMed).

Lehmann, Riethmüller, Johnson: "MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 24, pp. 9891-5, (1990) (PubMed).

Synonyme und alternative Namen zu COCH

cochlin (Coch), cochlin (COCH), AW122937, Coch-5B2, COCH-5B2, COCH5B2, D12H14S564E, DFNA9

Bezeichner auf Proteinebene für COCH

  • coagulation factor C homolog (Limulus polyphemus)
  • coagulation factor C homolog, cochlin (Limulus polyphemus)
  • cochlin
  • Coch-5B2
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