CRBN Produkte
(Cereblon (CRBN))
Kategorien
This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
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Ausgewählte CRBN Kategorien
CRBN Antikörper
High quality antibodies with extensive validation data.
CRBN ELISA Kits
Reliable ELISA kits for a wide range of species.
CRBN Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene CRBN Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, ELISA
Validierungen
- (3)
Kat. Nr.
ABIN7165198
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB
Validierungen
- (3)
- (1)
Kat. Nr.
ABIN526543
Menge
50 μg
Datenblatt
Datenblatt
Empfohlene CRBN ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6965629
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6954563
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6954564
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene CRBN Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN1350279
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7122244
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7122245
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren CRBN Produkten
: "Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome." in: eLife, Vol. 7, (2019) (PubMed).: "Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs." in: Bioorganic & medicinal chemistry, Vol. 27, Issue 12, pp. 2466-2479, (2019) (PubMed).
: "Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations." in: Nature communications, Vol. 10, Issue 1, pp. 3468, (2019) (PubMed).
: "Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of ..." in: Journal of medicinal chemistry, (2018) (PubMed).
: "Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation." in: Nature chemical biology, Vol. 14, Issue 2, pp. 163-170, (2018) (PubMed).
: "Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41." in: Cancer research, Vol. 76, Issue 12, pp. 3531-40, (2016) (PubMed).
: "Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 20, pp. 6772-89, (2014) (PubMed).
: "CRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis." in: Nature communications, Vol. 5, pp. 3924, (2014) (PubMed).
: "Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity." in: British journal of haematology, Vol. 164, Issue 2, pp. 233-44, (2014) (PubMed).
: "Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer." in: Oncogene, Vol. 30, Issue 33, pp. 3570-84, (2011) (PubMed).
Synonyme und alternative Namen zu CRBN
cereblon (crbn), cereblon (CRBN), ATP-dependent protease La (LON) domain protein (AT2G25740), cereblon (Crbn), 2610203G15Rik, 2900045O07Rik, AF229032, AW108261, F3N11.21, MRT2, mrt2a, MRT2A, piL, zgc:92404Bezeichner auf Proteinebene für CRBN
- protein cereblon
- zcrbn
- cereblon
- protein cereblon-like
- protein x 0001
- novel lethal
- protein PiL
- Protein cereblon
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