CRTC2 Produkte
(CREB Regulated Transcription Coactivator 2 (CRTC2))
Kategorien
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010].
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Ausgewählte CRTC2 Kategorien
CRTC2 Antikörper
High quality antibodies with extensive validation data.
CRTC2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene CRTC2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Rat
Applikation
WB, ELISA, IF, FACS
Validierungen
- (6)
Kat. Nr.
ABIN5539499
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, FACS, ICC
Validierungen
- (3)
- (4)
Kat. Nr.
ABIN969067
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, ELISA, FACS
Validierungen
- (4)
- (2)
Kat. Nr.
ABIN745988
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene CRTC2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6966120
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene CRTC2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1350407
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1350406
Menge
25 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7422235
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren CRTC2 Produkten
: "Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet." in: Archives of biochemistry and biophysics, Vol. 591, pp. 57-65, (2016) (PubMed).: "Transcriptional regulation of autophagy by an FXR-CREB axis." in: Nature, Vol. 516, Issue 7529, pp. 108-11, (2015) (PubMed).
: "CRTC2 enhances HBV transcription and replication by inducing PGC1? expression." in: Virology journal, Vol. 11, Issue 1, pp. 30, (2014) (PubMed).
: "Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 8, pp. 3339-50, (2014) (PubMed).
: "BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 4, pp. 1305-10, (2012) (PubMed).
: "Involvement of transducer of regulated cAMP response element-binding protein activity on corticotropin releasing hormone transcription." in: Endocrinology, Vol. 151, Issue 3, pp. 1109-18, (2010) (PubMed).
: "TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein." in: The Journal of biological chemistry, Vol. 284, Issue 12, pp. 8033-41, (2009) (PubMed).
: "Breaking human cytomegalovirus major immediate-early gene silence by vasoactive intestinal peptide stimulation of the protein kinase A-CREB-TORC2 signaling cascade in human pluripotent embryonal ..." in: Journal of virology, Vol. 83, Issue 13, pp. 6391-403, (2009) (PubMed).
: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).
: "Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2." in: Nature, Vol. 449, Issue 7160, pp. 366-9, (2007) (PubMed).
Synonyme und alternative Namen zu CRTC2
CREB regulated transcription coactivator 2 (CRTC2), CREB regulated transcription coactivator 2 (Crtc2), 4632407F12Rik, CRTC2, mTORC2, RGD1308903, TORC-2, TORC2, Torc2Bezeichner auf Proteinebene für CRTC2
- CREB regulated transcription coactivator 2
- CREB-regulated transcription coactivator 2
- CREB-regulated transcription coactivator 2-like
- transducer of regulated cAMP response element-binding protein (CREB) 2
- TORC-2
- transducer of CREB protein 2
- transducer of regulated cAMP response element-binding protein 2
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