DDB2 Produkte
(Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
Kategorien
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008].
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Ausgewählte DDB2 Kategorien
DDB2 Antikörper
High quality antibodies with extensive validation data.
DDB2 ELISA Kits
Reliable ELISA kits for a wide range of species.
DDB2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene DDB2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN3022632
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IF
Validierungen
- (3)
Kat. Nr.
ABIN7009799
Menge
60 μL
Datenblatt
Datenblatt
Reaktivität
Mouse, Rat
Applikation
WB, ELISA, IF (cc), IHC (p), IF (p), IHC (fro)
Validierungen
- (3)
Kat. Nr.
ABIN747803
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene DDB2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Validierungen
Kat. Nr.
ABIN1129989
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1129990
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Cow
Analytical Method
Validierungen
Kat. Nr.
ABIN1129987
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene DDB2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN1351259
Menge
25 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1351262
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1351260
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren DDB2 Produkten
: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." in: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).: "Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 5, pp. 1658-63, (2013) (PubMed).
: "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex." in: Genes & development, Vol. 22, Issue 18, pp. 2496-506, (2008) (PubMed).
: "Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC." in: Journal of cell science, Vol. 120, Issue Pt 15, pp. 2706-16, (2007) (PubMed).
: "Cullin 4A associates with the UV-damaged DNA-binding protein DDB." in: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35309-12, (2000) (PubMed).
: "The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription." in: Molecular and cellular biology, Vol. 19, Issue 7, pp. 4935-43, (1999) (PubMed).
Synonyme und alternative Namen zu DDB2
damage specific DNA binding protein 2 (DDB2), damage-specific DNA binding protein 2 (ddb2), damage specific DNA binding protein 2 (Ddb2), 2610043A19Rik, DDBB, si:dkey-45f10.3, UV-DDB2Bezeichner auf Proteinebene für DDB2
- damage-specific DNA binding protein 2 (48kD)
- damage-specific DNA binding protein 2, 48kDa
- DNA damage-binding protein 2
- Damage-specific DNA-binding protein 2
- DNA damage-binding protein 2-like
- damage-specific DNA-binding protein 2
- DDB p48 subunit
- UV-DDB 2
- UV-damaged DNA-binding protein 2
- xeroderma pigmentosum group E protein
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