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DDB2 Produkte

(Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008].

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Ausgewählte DDB2 Kategorien

DDB2 Antikörper

High quality antibodies with extensive validation data.

DDB2 ELISA Kits

Reliable ELISA kits for a wide range of species.

DDB2 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene DDB2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IF
Validierungen
  • (1)
  • (3)
Kat. Nr. ABIN3022632
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, IF
Validierungen
  • (3)
Kat. Nr. ABIN7009799
Menge 60 μL
Datenblatt Datenblatt
Reaktivität Mouse, Rat
Applikation WB, ELISA, IF (cc), IHC (p), IF (p), IHC (fro)
Validierungen
  • (3)
Kat. Nr. ABIN747803
Menge 100 μL
Datenblatt Datenblatt

Empfohlene DDB2 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method
Validierungen
Kat. Nr. ABIN1129989
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method
Validierungen
Kat. Nr. ABIN1129990
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Cow
Analytical Method
Validierungen
Kat. Nr. ABIN1129987
Menge 96 tests
Datenblatt Datenblatt

Empfohlene DDB2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN1351259
Menge 25 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1351262
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1351260
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren DDB2 Produkten

Xiang, Laurent, Hsu, Nachtergaele, Lu, Sheng, Xu, Chen, Ouyang, Wang, Ling, Hsu, Zou, Jambhekar, He, Shi: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." in: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).

Robu, Shah, Petitclerc, BrindAmour, Kandan-Kulangara, Shah: "Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 5, pp. 1658-63, (2013) (PubMed).

Abbas, Sivaprasad, Terai, Amador, Pagano, Dutta: "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex." in: Genes & development, Vol. 22, Issue 18, pp. 2496-506, (2008) (PubMed).

Luijsterburg, Goedhart, Moser, Kool, Geverts, Houtsmuller, Mullenders, Vermeulen, van Driel: "Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC." in: Journal of cell science, Vol. 120, Issue Pt 15, pp. 2706-16, (2007) (PubMed).

Shiyanov, Nag, Raychaudhuri: "Cullin 4A associates with the UV-damaged DNA-binding protein DDB." in: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35309-12, (2000) (PubMed).

Shiyanov, Hayes, Donepudi, Nichols, Linn, Slagle, Raychaudhuri: "The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription." in: Molecular and cellular biology, Vol. 19, Issue 7, pp. 4935-43, (1999) (PubMed).

Synonyme und alternative Namen zu DDB2

damage specific DNA binding protein 2 (DDB2), damage-specific DNA binding protein 2 (ddb2), damage specific DNA binding protein 2 (Ddb2), 2610043A19Rik, DDBB, si:dkey-45f10.3, UV-DDB2

Bezeichner auf Proteinebene für DDB2

  • damage-specific DNA binding protein 2 (48kD)
  • damage-specific DNA binding protein 2, 48kDa
  • DNA damage-binding protein 2
  • Damage-specific DNA-binding protein 2
  • DNA damage-binding protein 2-like
  • damage-specific DNA-binding protein 2
  • DDB p48 subunit
  • UV-DDB 2
  • UV-damaged DNA-binding protein 2
  • xeroderma pigmentosum group E protein
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