DDR2 Produkte
(Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))
Kategorien
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
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Ausgewählte DDR2 Kategorien
DDR2 Antikörper
High quality antibodies with extensive validation data.
DDR2 ELISA Kits
Reliable ELISA kits for a wide range of species.
DDR2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene DDR2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p), FACS
Validierungen
- (4)
Kat. Nr.
ABIN392069
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC, ICC
Validierungen
- (3)
- (3)
Kat. Nr.
ABIN969083
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, FACS
Validierungen
- (5)
Kat. Nr.
ABIN3030741
Menge
0.4 mL
Datenblatt
Datenblatt
Empfohlene DDR2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6966390
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6955409
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN4886342
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene DDR2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (2)
Kat. Nr.
ABIN7274461
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
HEK-293 Cells
Validierungen
- (2)
Kat. Nr.
ABIN7274463
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Baculovirus infected Insect Cells
Validierungen
- (1)
Kat. Nr.
ABIN5854620
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren DDR2 Produkten
: "Hypoxia-induced H19/YB-1 cascade modulates cardiac remodeling after infarction." in: Theranostics, Vol. 9, Issue 22, pp. 6550-6567, (2019) (PubMed).: "Targeting DDR2 in head and neck squamous cell carcinoma with dasatinib." in: International journal of cancer, Vol. 139, Issue 10, pp. 2359-69, (2016) (PubMed).
: "NPY1-36 and PYY1-36 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4." in: American journal of physiology. Heart and circulatory physiology, Vol. 309, Issue 9, pp. H1528-42, (2015) (PubMed).
: "NSCLC Driven by DDR2 Mutation Is Sensitive to Dasatinib and JQ1 Combination Therapy." in: Molecular cancer therapeutics, Vol. 14, Issue 10, pp. 2382-9, (2015) (PubMed).
: "DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1." in: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 101, (2015) (PubMed).
: "Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation." in: Circulation research, Vol. 115, Issue 7, pp. 625-35, (2014) (PubMed).
: "Angiotensin II upregulates K(Ca)3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts." in: Biochemical pharmacology, Vol. 85, Issue 10, pp. 1486-94, (2013) (PubMed).
: "Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. ..." in: Cancer discovery, Vol. 1, Issue 1, pp. 78-89, (2012) (PubMed).
: "The discoidin domain receptor DDR2 is a receptor for type X collagen." in: Matrix biology : journal of the International Society for Matrix Biology, Vol. 25, Issue 6, pp. 355-64, (2006) (PubMed).
: "Regulation of discoidin domain receptor 2 by cyclic mechanical stretch in cultured rat vascular smooth muscle cells." in: Hypertension, Vol. 46, Issue 3, pp. 614-21, (2005) (PubMed).
Synonyme und alternative Namen zu DDR2
discoidin domain receptor tyrosine kinase 2 (DDR2), discoidin domain receptor family, member 2 (Ddr2), discoidin domain receptor tyrosine kinase 2 (Ddr2), discoidin domain receptor family, member 2, like (ddr2l), AW495251, DDR2, ddr2, MIG20a, NTRKR3, Ntrkr3, si:ch211-193c2.1, TKT, TYRO10, tyro10, Tyro10Bezeichner auf Proteinebene für DDR2
- CD167 antigen-like family member B
- cell migration-inducing protein 20
- discoidin domain receptor 2
- discoidin domain receptor family, member 2
- discoidin domain-containing receptor 2
- discoidin domain-containing receptor tyrosine kinase 2
- hydroxyaryl-protein kinase
- migration-inducing gene 16 protein
- neurotrophic tyrosine kinase receptor related 3
- neurotrophic tyrosine kinase, receptor-related 3
- receptor protein-tyrosine kinase TKT
- tyrosine-protein kinase TYRO10
- tyrosylprotein kinase
- discoidin domain receptor tyrosine kinase 2
- CD167b antigen
- tyrosine-protein kinase TYRO 10
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