DHX58 Produkte
(DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))
Kategorien
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
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Ausgewählte DHX58 Kategorien
DHX58 Antikörper
High quality antibodies with extensive validation data.
DHX58 ELISA Kits
Reliable ELISA kits for a wide range of species.
DHX58 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene DHX58 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
ELISA, FACS
Validierungen
- (4)
Kat. Nr.
ABIN5542450
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, FACS
Validierungen
- (4)
Kat. Nr.
ABIN5542451
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC
Validierungen
- (3)
Kat. Nr.
ABIN7164384
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene DHX58 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN3198476
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Chicken
Analytical Method
Validierungen
Kat. Nr.
ABIN1773426
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Sheep
Analytical Method
Validierungen
Kat. Nr.
ABIN1774650
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene DHX58 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1351580
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3092156
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3136923
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren DHX58 Produkten
: "DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy." in: BMC biology, Vol. 18, Issue 1, pp. 32, (2020) (PubMed).: "Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs." in: Oncotarget, Vol. 7, Issue 18, pp. 26496-515, (2018) (PubMed).
: "Comparative analysis of viral RNA signatures on different RIG-I-like receptors." in: eLife, Vol. 5, pp. e11275, (2016) (PubMed).
: "Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 2, pp. 582-7, (2007) (PubMed).
: "RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2." in: Journal of virology, Vol. 80, Issue 24, pp. 12332-42, (2006) (PubMed).
: "Pathogen recognition and innate immunity." in: Cell, Vol. 124, Issue 4, pp. 783-801, (2006) (PubMed).
: "The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 49, pp. 17264-9, (2004) (PubMed).
: "Toll-like receptor control of the adaptive immune responses." in: Nature immunology, Vol. 5, Issue 10, pp. 987-95, (2004) (PubMed).
Synonyme und alternative Namen zu DHX58
DEXH-box helicase 58 L homeolog (dhx58.L), DExH-box helicase 58 (DHX58), DExH-box helicase 58 (dhx58), probable ATP-dependent RNA helicase DHX58 (LOC100566102), DEXH (Asp-Glu-X-His) box polypeptide 58 (dhx58), DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58), DEXH-box helicase 58 (Dhx58), B430001I08Rik, D11LGP2, D11lgp2e, D11Lgp2e, DHX58, lgp2, LGP2, Lgp2, LPG2, MGC82787, RGD1310093, RLR-3Bezeichner auf Proteinebene für DHX58
- DEXH (Asp-Glu-X-His) box polypeptide 58
- probable ATP-dependent RNA helicase DHX58
- probable ATP-dependent RNA helicase DHX58-like
- Probable ATP-dependent RNA helicase DHX58
- RIG-I-like receptor 3
- RIG-I-like receptor LGP2
- RLR
- RNA helicase LGP2
- ortholog of mouse D11lgp2
- probable ATP-dependent helicase LGP2
- protein D11Lgp2 homolog
- RIG-I-like receptor Lgp2
- protein D11Lgp2
- ATP-dependent RNA helicase DHX58
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