Dual Specificity Phosphatase 3 Produkte
(Dual Specificity Phosphatase 3 (DUSP3))
Kategorien
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008].
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Ausgewählte Dual Specificity Phosphatase 3 Kategorien
Dual Specificity Phosphatase 3 Antikörper
High quality antibodies with extensive validation data.
Dual Specificity Phosphatase 3 ELISA Kits
Reliable ELISA kits for a wide range of species.
Dual Specificity Phosphatase 3 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Dual Specificity Phosphatase 3 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, ICC, IP
Validierungen
- (4)
Kat. Nr.
ABIN7426586
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p)
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN392924
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF
Validierungen
- (4)
Kat. Nr.
ABIN560661
Menge
50 μg
Datenblatt
Datenblatt
Empfohlene Dual Specificity Phosphatase 3 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN5591980
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN4885040
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6384474
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene Dual Specificity Phosphatase 3 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7122713
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN667577
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1352132
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Dual Specificity Phosphatase 3 Produkten
: "Vaccinia H1-related phosphatase is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancer." in: The Journal of biological chemistry, Vol. 286, Issue 12, pp. 10177-84, (2011) (PubMed).: "Protein tyrosine phosphatases: structure-function relationships." in: The FEBS journal, Vol. 275, Issue 5, pp. 867-82, (2008) (PubMed).
: "Tyrosine phosphorylation of VHR phosphatase by ZAP-70." in: Nature immunology, Vol. 4, Issue 1, pp. 44-8, (2002) (PubMed).
: "Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4766-71, (2001) (PubMed).
: "Crystal structure of the dual specificity protein phosphatase VHR." in: Science (New York, N.Y.), Vol. 272, Issue 5266, pp. 1328-31, (1996) (PubMed).
: "Human dual specificity phosphatase VHR activates maturation promotion factor and triggers meiotic maturation in Xenopus oocytes." in: The Journal of biological chemistry, Vol. 270, Issue 23, pp. 14229-34, (1995) (PubMed).
: "Expression cloning of a human dual-specificity phosphatase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 24, pp. 12170-4, (1993) (PubMed).
Synonyme und alternative Namen zu Dual Specificity Phosphatase 3
dual specificity phosphatase 3 (DUSP3), dual specificity phosphatase 3b (dusp3b), dual specificity phosphatase 3 (Dusp3), dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), 2210015O03Rik, 5031436O03Rik, dusp3, RGD1560049, si:bz18k17.3, si:rp71-18k17.3, T-DSP11, VHRBezeichner auf Proteinebene für Dual Specificity Phosphatase 3
- dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
- dual specificity phosphatase 3
- dual specificity protein phosphatase 3
- dual specificity protein phosphatase VHR
- serine/threonine specific protein phosphatase
- vaccinia H1-related phosphatase
- vaccinia virus phosphatase VH1-related
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