Dystrophin Produkte
(Dystrophin (DMD))
Kategorien
The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as encoded by the Dp427 transcripts) is a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix. [provided by RefSeq, Jul 2008].
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Ausgewählte Dystrophin Kategorien
Dystrophin Antikörper
High quality antibodies with extensive validation data.
Dystrophin ELISA Kits
Reliable ELISA kits for a wide range of species.
Dystrophin Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Dystrophin Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF
Validierungen
- (5)
Kat. Nr.
ABIN1679546
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC, IF
Validierungen
- (4)
Kat. Nr.
ABIN7008615
Menge
60 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IP, ELISA
Validierungen
- (4)
Kat. Nr.
ABIN515027
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene Dystrophin ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6966439
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6966438
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6955484
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene Dystrophin Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1351717
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7420834
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7394210
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Dystrophin Produkten
: "In vivo cerebellar circuit function is disrupted in an mdx mouse model of Duchenne muscular dystrophy." in: Disease models & mechanisms, Vol. 13, Issue 2, (2019) (PubMed).: "Immunohistochemical study on dystrophin expression in CAD-related sudden cardiac death: a marker of early myocardial ischaemia." in: International journal of legal medicine, Vol. 132, Issue 5, pp. 1333-1339, (2018) (PubMed).
: "Dipeptidyl Peptidase 4 Inhibition Alleviates Shortage of Circulating Glucagon-Like Peptide-1 in Heart Failure and Mitigates Myocardial Remodeling and Apoptosis via the Exchange Protein Directly ..." in: Circulation. Heart failure, Vol. 9, Issue 1, pp. e002081, (2016) (PubMed).
: "Isolation and characterization of neural stem cells from dystrophic mdx mouse." in: Experimental cell research, Vol. 343, Issue 2, pp. 190-207, (2016) (PubMed).
: "Evidence for the involvement of the CXCL12 system in the adaptation of skeletal muscles to physical exercise." in: Cellular signalling, Vol. 28, Issue 9, pp. 1205-15, (2016) (PubMed).
: "A dipeptidyl peptidase-4 inhibitor ameliorates hypertensive cardiac remodeling via angiotensin-II/sodium-proton pump exchanger-1 axis." in: Journal of molecular and cellular cardiology, Vol. 98, pp. 37-47, (2016) (PubMed).
: "Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcoma." in: Cancer genetics, Vol. 205, Issue 5, pp. 232-41, (2012) (PubMed).
: "Monoclonal antibodies for dystrophin analysis. Epitope mapping and improved binding to SDS-treated muscle sections." in: The Biochemical journal, Vol. 288 ( Pt 2), pp. 663-8, (1993) (PubMed).
: "A quantitative ELISA for dystrophin." in: Journal of immunological methods, Vol. 161, Issue 1, pp. 23-8, (1993) (PubMed).
Synonyme und alternative Namen zu Dystrophin
dystrophin (DMD), dystrophin (LOC708073), dystrophin, gene 1 L homeolog (dmd.1.L), dystrophin (LOC465557), dystrophin, gene 1 (dmd.1), dystrophin (dmd), dystrophin, muscular dystrophy (Dmd), dystrophin (Dmd), Dystrophin (Dys), BMD, cb664, CG7240, CG7243, CG7344, CG17750, CG31175, CG34157, CMD3B, det, DKFZp459C1629, DKFZp468A1620, DLP, DLP1, DLP2, DLP3, DLP186, DMD, Dmd, dmd, DmDLP, dmDLP, dmDp186, DmDYS, dmDys, Dmel\\CG34157, DNADMD1, Dp71, Dp117, Dp186, Dp205, Dp427, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, DXSmh7, DXSmh9, dys, GI3046716, IDLP, im:6911785, mdx, MGC79631, MGC83347, pke, RATDMD, zfDYS, zgc:110165Bezeichner auf Proteinebene für Dystrophin
- dystrophin (muscular dystrophy, Duchenne and Becker types)
- dystrophin
- Duchenne muscular dystrophy
- dystrophin isoform Dp116
- sap
- sapje
- dystrophin Dp71 isoform
- X-linked muscular dystrophy
- RNDNADMD1
- apodystrophin-3
- apodystrophin-I
- dystrophin transcript variant Dp71e
- dystrophin, muscular dystrophy
- CG34157-PA
- CG34157-PB
- CG34157-PC
- CG34157-PD
- CG34157-PE
- CG34157-PF
- CG34157-PG
- CG34157-PH
- CG34157-PI
- CG34157-PJ
- CG34157-PK
- CG34157-PL
- Dys-PA
- Dys-PB
- Dys-PC
- Dys-PD
- Dys-PE
- Dys-PF
- Dys-PG
- Dys-PH
- Dys-PI
- Dys-PJ
- Dys-PK
- Dys-PL
- Dystrophin-like protein 1
- Dystrophin-like protein 186
- Dystrophin-like protein 2
- Dystrophin-like protein 3
- detached
- dystrophin Dp186
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