EIF3E Produkte
(Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))
Kategorien
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. {ECO:0000255|HAMAP-Rule:MF_03004}.
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Ausgewählte EIF3E Kategorien
EIF3E Antikörper
High quality antibodies with extensive validation data.
EIF3E Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene EIF3E Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Applikation
WB, IHC
Validierungen
- (5)
Kat. Nr.
ABIN2783260
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Zebrafish (Danio rerio)
Applikation
WB
Validierungen
- (5)
- (2)
Kat. Nr.
ABIN1881290
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (3)
Kat. Nr.
ABIN561508
Menge
50 μL
Datenblatt
Datenblatt
Empfohlene EIF3E Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1352556
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1352558
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
Kat. Nr.
ABIN2720079
Menge
20 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren EIF3E Produkten
: "An oncogenic role of eIF3e/INT6 in human breast cancer." in: Oncogene, Vol. 29, Issue 28, pp. 4080-9, (2010) (PubMed).: "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18139-44, (2008) (PubMed).
: "Human INT6/eIF3e is required for nonsense-mediated mRNA decay." in: EMBO reports, Vol. 8, Issue 6, pp. 596-602, (2007) (PubMed).
: "Reconstitution reveals the functional core of mammalian eIF3." in: The EMBO journal, Vol. 26, Issue 14, pp. 3373-83, (2007) (PubMed).
: "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells." in: Biological chemistry, Vol. 388, Issue 5, pp. 457-65, (2007) (PubMed).
: "A new common integration site, Int7, for the mouse mammary tumor virus in mouse mammary tumors identifies a gene whose product has furin-like and thrombospondin-like sequences." in: Journal of virology, Vol. 79, Issue 15, pp. 10093-6, (2005) (PubMed).
: "Int6 expression can predict survival in early-stage non-small cell lung cancer patients." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 9, pp. 3198-204, (2005) (PubMed).
: "Fission yeast Int6 is not essential for global translation initiation, but deletion of int6(+) causes hypersensitivity to caffeine and affects spore formation." in: Molecular biology of the cell, Vol. 11, Issue 11, pp. 4005-18, (2001) (PubMed).
Synonyme und alternative Namen zu EIF3E
eukaryotic translation initiation factor 3 subunit E (EIF3E), eukaryotic translation initiation factor 3, subunit E (Eif3e), eukaryotic translation initiation factor 3 subunit E (eif3e), eukaryotic translation initiation factor 3 subunit E L homeolog (eif3e.L), eukaryotic translation initiation factor 3 subunit 6 (LOC692936), eukaryotic translation initiation factor 3 subunit E S homeolog (eif3e.S), eukaryotic translation initiation factor 3, subunit E, a (eif3ea), Eukaryotic translation initiation factor 3 subunit E (eif-3.E), eukaryotic translation initiation factor 3, subunit E, b (eif3eb), eukaryotic translation initiation factor 3 subunit E (Eif3e), eukaryotic translation initiation factor 3 subunit E (LOC108348260), eukaryotic translation initiation factor 3 subunit E (int6), 48kDa, eIF3-p46, EIF3-P48, eIF3-p48, eif3-p48, eIF3-S6, eIF3e, EIF3S6, Eif3s6, eif3s6, eif3s6-A, eif3s6-B, eif3s6b, EIF3SE, im:7147439, INT6, Int6, QtsA-18056Bezeichner auf Proteinebene für EIF3E
- eIF-3 p48
- eukaryotic translation initiation factor 3 subunit 6
- eukaryotic translation initiation factor 3 subunit E
- eukaryotic translation initiation factor 3, subunit 6 (48kD)
- eukaryotic translation initiation factor 3, subunit 6 48kDa
- mammary tumor-associated protein INT6
- murine mammary tumor integration site 6 (oncogene homolog)
- viral integration site protein INT-6 homolog
- MMTV integration site 6
- mammary tumor integration site 6
- mammary tumor-associated protein INT-6
- viral integration site protein INT-6
- eukaryotic translation initiation factor 3, subunit 6
- eukaryotic translation initiation factor 3 subunit E-A
- Eukaryotic translation initiation factor 3 subunit 6-A
- eukaryotic translation initiation factor 3 subunit E-B
- Eukaryotic translation initiation factor 3 subunit 6-B
- eukaryotic translation initiation factor 3, subunit E
- Eukaryotic translation initiation factor 3 subunit 6
- eukaryotic translation initiation factor 3 subunit E-like
- eIF3e-B
- eukaryotic translation initiation factor 3 subunit 6-B
- eukaryotic translation initiation factor 3, subunit 6b
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