ELANE Produkte
(Elastase, Neutrophil Expressed (ELANE))
Kategorien
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009].
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Ausgewählte ELANE Kategorien
ELANE Antikörper
High quality antibodies with extensive validation data.
ELANE ELISA Kits
Reliable ELISA kits for a wide range of species.
ELANE Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene ELANE Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
ELISA, WB, IHC, FACS
Validierungen
- (6)
Kat. Nr.
ABIN5611333
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (7)
Kat. Nr.
ABIN6140110
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (5)
Kat. Nr.
ABIN7431269
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene ELANE ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (2)
- (1)
Kat. Nr.
ABIN6955518
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6955517
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (3)
- (1)
Kat. Nr.
ABIN6955519
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene ELANE Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1352646
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7389194
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren ELANE Produkten
: "Effect of antimicrobial peptides HNP-1 and hBD-1 on Staphylococcus aureus strains in vitro and in vivo." in: Fundamental & clinical pharmacology, Vol. 34, Issue 1, pp. 102-108, (2020) (PubMed).: "Erythromycin suppresses neutrophil extracellular traps in smoking-related chronic pulmonary inflammation." in: Cell death & disease, Vol. 10, Issue 9, pp. 678, (2020) (PubMed).
: "Neutrophil Extracellular Traps Associate with Clinical Stages in Breast Cancer." in: Pathology oncology research : POR, Vol. 26, Issue 3, pp. 1781-1785, (2020) (PubMed).
: "MiR-608 Exerts Anti-inflammatory Effects by Targeting ELANE in Monocytes." in: Journal of clinical immunology, Vol. 40, Issue 1, pp. 147-157, (2020) (PubMed).
: "Inhibition of microRNA-146a attenuated heart failure in myocardial infarction rats." in: Bioscience reports, Vol. 39, Issue 12, (2020) (PubMed).
: "Neutrophil Elastase Inhibitors Suppress Oxidative Stress in Lung during Liver Transplantation." in: Oxidative medicine and cellular longevity, Vol. 2019, pp. 7323986, (2020) (PubMed).
: "Levels of pro- and anti-inflammatory cytokines in cystic fibrosis patients with or without gingivitis." in: Cytokine, Vol. 127, pp. 154987, (2020) (PubMed).
: "Corneal epithelial injury-induced norepinephrine promotes Pseudomonas aeruginosa keratitis." in: Experimental eye research, Vol. 195, pp. 108048, (2020) (PubMed).
: "Possible mechanisms of prenatal cold stress induced-anxiety-like behavior depression in offspring rats." in: Behavioural brain research, Vol. 359, pp. 304-311, (2019) (PubMed).
: "Angiotensin II Type 1a Receptors in the Subfornical Organ Modulate Neuroinflammation in the Hypothalamic Paraventricular Nucleus in Heart Failure Rats." in: Neuroscience, Vol. 381, pp. 46-58, (2019) (PubMed).
Synonyme und alternative Namen zu ELANE
elastase, neutrophil expressed (ELANE), elastase, neutrophil expressed (Elane), proteinase 3 (prtn3), ELA2, Ela2, ela2, ELANE, F430011M15Rik, GE, HLE, HNE, NE, PMN-E, SCN1Bezeichner auf Proteinebene für ELANE
- PMN elastase
- bone marrow serine protease
- elastase 2, neutrophil
- elastase-2
- granulocyte-derived elastase
- human leukocyte elastase
- leukocyte elastase
- medullasin
- neutrophil elastase
- polymorphonuclear elastase
- serine protease
- elastase, neutrophil expressed
- LOW QUALITY PROTEIN: neutrophil elastase
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