ERBB3 Produkte
(Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
Kategorien
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
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Ausgewählte ERBB3 Kategorien
ERBB3 Antikörper
High quality antibodies with extensive validation data.
ERBB3 ELISA Kits
Reliable ELISA kits for a wide range of species.
ERBB3 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene ERBB3 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Applikation
WB, IHC, IP, ICC
Validierungen
- (6)
Kat. Nr.
ABIN7440773
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IHC (p), FACS
Validierungen
- (4)
- (5)
Kat. Nr.
ABIN391949
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro)
Validierungen
- (4)
Kat. Nr.
ABIN747113
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene ERBB3 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validierungen
- (3)
Kat. Nr.
ABIN1981720
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6959065
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6959066
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene ERBB3 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (5)
Kat. Nr.
ABIN7274801
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7274797
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Cynomolgus, Rhesus Monkey
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7274795
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren ERBB3 Produkten
: "EV20‑sss‑vc/MMAF, an HER‑3 targeting antibody‑drug conjugate displays antitumor activity in liver cancer." in: Oncology reports, Vol. 45, Issue 2, pp. 776-785, (2021) (PubMed).: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." in: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).
: "EV20-mediated delivery of cytotoxic auristatin MMAF exhibits potent therapeutic efficacy in cutaneous melanoma." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 277, pp. 48-56, (2019) (PubMed).
: "Soluble HER3 predicts survival in bladder cancer patients." in: Oncology letters, Vol. 15, Issue 2, pp. 1783-1788, (2018) (PubMed).
: "Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients." in: BMC cancer, Vol. 17, Issue 1, pp. 841, (2018) (PubMed).
: "Exogenous HGF Bypasses the Effects of ErbB Inhibition on Tumor Cell Viability in Medulloblastoma Cell Lines." in: PLoS ONE, Vol. 10, Issue 10, pp. e0141381, (2015) (PubMed).
: "A phosphoproteomic screen demonstrates differential dependence on HER3 for MAP kinase pathway activation by distinct PIK3CA mutations." in: Proteomics, Vol. 15, Issue 2-3, pp. 318-26, (2015) (PubMed).
: "HER2 missense mutations have distinct effects on oncogenic signaling and migration. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 45, pp. E6205-14, (2015) (PubMed).
: "A novel function of HER2/Neu in the activation of G2/M checkpoint in response to γ-irradiation." in: Oncogene, Vol. 34, Issue 17, pp. 2215-26, (2015) (PubMed).
: "A Novel Antibody Engineering Strategy for Making Monovalent Bispecific Heterodimeric IgG Antibodies by Electrostatic Steering Mechanism." in: The Journal of biological chemistry, (2015) (PubMed).
Synonyme und alternative Namen zu ERBB3
erb-b2 receptor tyrosine kinase 3 (ERBB3), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), erb-b2 receptor tyrosine kinase 3 (Erbb3), c-erbB-3, c-erbB3, C76256, ErbB-3, Erbb-3, ERBB3, erbB3-S, Erbb3r, HER3, Her3, LCCS2, MDA-BF-1, nuc-ErbB3, p45-sErbB3, p85-sErbB3, p180-ErbB3Bezeichner auf Proteinebene für ERBB3
- proto-oncogene-like protein c-ErbB-3
- receptor tyrosine-protein kinase erbB-3
- tyrosine kinase-type cell surface receptor HER3
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- receptor tyrosine kinase ErbB3
- receptor tyrosine-protein kinase erbB-3-like
- avian erythroblastosis oncogene B 3 receptor
- c-erbB-3
- glial growth factor receptor
- receptor tyrosine kinase
- avian erythroblastosis oncogene B 3
- c-erbB3
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
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