EXOSC10 Produkte
(Exosome Component 10 (EXOSC10))
Kategorien
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA (By similarity).
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Ausgewählte EXOSC10 Kategorien
EXOSC10 Antikörper
High quality antibodies with extensive validation data.
EXOSC10 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene EXOSC10 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Applikation
WB
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN2778684
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC
Validierungen
- (2)
Kat. Nr.
ABIN1714746
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (2)
Kat. Nr.
ABIN518993
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene EXOSC10 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6226645
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene EXOSC10 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1353233
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1353232
Menge
25 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3134522
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren EXOSC10 Produkten
: "An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression." in: Genes & development, (2017) (PubMed).: "Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis." in: Cell reports, Vol. 13, Issue 8, pp. 1610-22, (2015) (PubMed).
: "RNAP II CTD tyrosine 1 performs diverse functions in vertebrate cells." in: eLife, Vol. 3, pp. e02112, (2014) (PubMed).
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage." in: Genes & development, Vol. 27, Issue 20, pp. 2227-32, (2013) (PubMed).
: "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways." in: RNA (New York, N.Y.), Vol. 13, Issue 7, pp. 1027-35, (2007) (PubMed).
Synonyme und alternative Namen zu EXOSC10
exosome component 10 (exosc10), exosome component 10 (EXOSC10), exosome component 10 (EHI_021400), exosome component 10 (BBOV_IV002650), exosome component 10 (CpipJ_CPIJ003896), exosome component 10 (CMU_031760), 3'-5' exonuclease (exosc10), exosome component 10 (Tsp_05247), exosome component 10 L homeolog (exosc10.L), exosome component 10 (Exosc10), 21.m02990, 201.t00018, DDBDRAFT_0203581, DDBDRAFT_0233752, DDB_0203581, DDB_0233752, EXOSC10, p2, p3, p4, pm-scl, PM-Scl, pm/scl-100, PM/Scl-100, pmscl, PMSCL, Pmscl2, pmscl2, PMSCL2, rrp6, RRP6, rrp6p, Rrp6p, zgc:55695Bezeichner auf Proteinebene für EXOSC10
- exosome component 10
- Exosome component 10
- P100 polymyositis-scleroderma overlap syndrome-associated autoantigen
- autoantigen PM-SCL
- autoantigen PM/Scl 2
- polymyositis/scleroderma autoantigen 100 kDa
- polymyositis/scleroderma autoantigen 2 (100kD)
- polymyositis/scleroderma autoantigen 2, 100kDa
- autoantigen PM/Scl 2 homolog
- polymyositis/scleroderma autoantigen 2 homolog
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