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FAM208A Antikörper (AA 700-1000)

FAM208A Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6140453
  • Target
    FAM208A (Family with Sequence Similarity 208, Member A (FAM208A))
    Bindungsspezifität
    AA 700-1000
    Reaktivität
    Human
    Wirt
    Kaninchen
    Klonalität
    Polyklonal
    Applikation
    Western Blotting (WB)
    Sequenz
    DTEDMRSKTV LKRKLEDLPE NMRKLAKTSN LSENCHLYEE SPQPIGSLGH DADLRRQQQD TCNSGIADIH RLFNWLSETL ANARHSDASL TDTVNKALGL STDDAYEELR QKHEYELNST PDKKDYEQPT CAKVENAQFK GTQSLLLEVD ATSKYSVAIS TSEVGTDHKL HLKEDPNLIS VNNFEDCSLC PSVPIEHGFR RQQSKSNNVE ETEIHWKLIP ITGGNARSPE DQLGKHGEKQ TPGMKSPEEQ LVCVPPQEAF PNDPRVINRQ RSSDYQFPSS PFTDTLKGTT EDDVLTGQVE E
    Kreuzreaktivität
    Human
    Produktmerkmale
    Polyclonal Antibodies
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human FAM208A (NP_001106207.1).
    Isotyp
    IgG
  • Applikationshinweise
    WB,1:500 - 1:2000
    Kommentare

    HIGH QUALITY

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    FAM208A (Family with Sequence Similarity 208, Member A (FAM208A))
    Andere Bezeichnung
    FAM208A
    Synonyme
    c3orf63-a antikoerper, c3orf63.1 antikoerper, fam208a antikoerper, rap140 antikoerper, se89-1 antikoerper, C3orf63 antikoerper, RAP140 antikoerper, family with sequence similarity 208 member A L homeolog antikoerper, family with sequence similarity 208 member A antikoerper, fam208a.L antikoerper, FAM208A antikoerper
    Hintergrund
    Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. Plays a crucial role in early embryonic development (By similarity. Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity. Plays an important role in maintaining epiblast fitness or potency (By similarity.,FAM208A,C3orf63,RAP140,TASOR,se89-1,Epigenetics & Nuclear Signaling,RNA Binding,FAM208A
    Molekulargewicht
    139 kDa/170 kDa/182 kDa/189 kDa
    Gen-ID
    23272
    UniProt
    Q9UK61
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