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FBXO11 Produkte

(F-Box Protein 11 (FBXO11))

Kategorien

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010].

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Ausgewählte FBXO11 Kategorien

FBXO11 Antikörper

High quality antibodies with extensive validation data.

FBXO11 ELISA Kits

Reliable ELISA kits for a wide range of species.

FBXO11 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene FBXO11 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, IF, IHC (p)
Validierungen
  • (4)
Kat. Nr. ABIN566432
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validierungen
  • (2)
Kat. Nr. ABIN1386847
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse
Applikation WB, IF
Validierungen
  • (2)
Kat. Nr. ABIN7261998
Menge 200 μL
Datenblatt Datenblatt

Empfohlene FBXO11 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Sheep
Analytical Method
Validierungen
Kat. Nr. ABIN1773981
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Competition ELISA
Validierungen
Kat. Nr. ABIN1743076
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Dog
Analytical Method
Validierungen
Kat. Nr. ABIN1769085
Menge 96 tests
Datenblatt Datenblatt

Empfohlene FBXO11 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1353767
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr. ABIN3089172
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Mouse
Source Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr. ABIN3121953
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren FBXO11 Produkten

Clijsters, Hoencamp, Calis, Marzio, Handgraaf, Cuitino, Rosenberg, Leone, Pagano: "Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs." in: Molecular cell, Vol. 74, Issue 6, pp. 1264-1277.e7, (2019) (PubMed).

Pagan, Marzio, Jones, Saraf, Jallepalli, Florens, Washburn, Pagano: "Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing." in: Nature cell biology, Vol. 17, Issue 1, pp. 31-43, (2014) (PubMed).

Horn, Geisen, Cermak, Becker, Nakamura, Klein, Pagano, Antebi: "DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation." in: Developmental cell, Vol. 28, Issue 6, pp. 697-710, (2014) (PubMed).

Rossi, Duan, Jeong, Horn, Saraf, Florens, Washburn, Antebi, Pagano: "Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase." in: Molecular cell, Vol. 49, Issue 6, pp. 1159-66, (2013) (PubMed).

Duan, Cermak, Pagan, Rossi, Martinengo, di Celle, Chapuy, Shipp, Chiarle, Pagano: "FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas." in: Nature, Vol. 481, Issue 7379, pp. 90-3, (2012) (PubMed).

Lee, Pal, Tasaki, Roy, Jiang, An, Banerjee, Kwon: "Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 1, pp. 100-5, (2008) (PubMed).

Synonyme und alternative Namen zu FBXO11

F-box protein 11 (FBXO11), F-box protein 11 (Fbxo11), F-box protein 11 L homeolog (fbxo11.L), F-box protein 11a (fbxo11a), F-box only protein 11 (CpipJ_CPIJ009919), F-box only protein 11 (CpipJ_CPIJ017549), F-box only protein 11 (Bm1_52225), hypothetical protein (LOAG_16571), F-box protein 11 (fbxo11), F-box protein 11 (LOC100115478), C80048, DKFZp459P2410, FBX11, fbxo11, FBXO11, Fbxo11, im:6906507, Jf, MGC84634, PRMT9, UBR6, VIT1, Vit1, wu:fj83f06, zgc:153171

Bezeichner auf Proteinebene für FBXO11

  • F-box only protein 11
  • protein arginine N-methyltransferase 9
  • ubiquitin protein ligase E3 component n-recognin 6
  • vitiligo-associated protein 1
  • vitiligo-associated protein VIT-1
  • GENA 104
  • jeff
  • F-box protein 11
  • fj83f06
  • F-box only protein 11-like
  • f-box only protein 11-like
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