FBXW7 Produkte
(F-Box and WD Repeat Domain Containing 7 (FBXW7))
Kategorien
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012].
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Ausgewählte FBXW7 Kategorien
FBXW7 Antikörper
High quality antibodies with extensive validation data.
FBXW7 ELISA Kits
Reliable ELISA kits for a wide range of species.
FBXW7 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene FBXW7 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Applikation
WB, IHC
Validierungen
- (1)
- (7)
Kat. Nr.
ABIN2782955
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro)
Validierungen
- (2)
- (3)
Kat. Nr.
ABIN1386103
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC (p)
Validierungen
- (5)
- (3)
Kat. Nr.
ABIN527479
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene FBXW7 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Competition ELISA
Validierungen
Kat. Nr.
ABIN1743138
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Sheep
Analytical Method
Validierungen
Kat. Nr.
ABIN1774043
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Dog
Analytical Method
Validierungen
Kat. Nr.
ABIN1769147
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene FBXW7 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1353879
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1990130
Menge
25 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3092548
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren FBXW7 Produkten
: "miR‑223‑3p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors." in: International journal of oncology, Vol. 50, Issue 2, pp. 356-364, (2016) (PubMed).: "Dysfunction of microRNA-32 regulates ubiquitin ligase FBXW7 in multiple myeloma disease." in: OncoTargets and therapy, Vol. 9, pp. 6573-6579, (2016) (PubMed).
: "F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner." in: The Journal of clinical investigation, Vol. 125, Issue 2, pp. 621-35, (2015) (PubMed).
: "RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway." in: Biochemical and biophysical research communications, Vol. 454, Issue 1, pp. 71-7, (2015) (PubMed).
: "Fbxw7 regulates hepatocellular carcinoma migration and invasion via Notch1 signaling pathway." in: International journal of oncology, Vol. 47, Issue 1, pp. 231-43, (2015) (PubMed).
: "Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length." in: The EMBO journal, Vol. 34, Issue 19, pp. 2424-40, (2015) (PubMed).
: "Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry." in: Cell death and differentiation, Vol. 22, Issue 11, pp. 1775-84, (2015) (PubMed).
: "FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC." in: Oncotarget, Vol. 6, Issue 14, pp. 12697-709, (2015) (PubMed).
: "STAT1 inhibits human hepatocellular carcinoma cell growth through induction of p53 and Fbxw7." in: Cancer cell international, Vol. 15, pp. 111, (2015) (PubMed).
: "FBXW7 mediates chemotherapeutic sensitivity and prognosis in NSCLCs." in: Molecular cancer research : MCR, Vol. 12, Issue 1, pp. 32-7, (2014) (PubMed).
Synonyme und alternative Namen zu FBXW7
F-box and WD repeat domain containing 7 (Fbxw7), F-box and WD repeat domain containing 7 (FBXW7), F-box and WD repeat domain containing 7 (fbxw7), F-box and WD-40 domain protein 7 (Fbxw7), 1110001A17Rik, AGO, cdc4, CDC4, Cdc4, FBW6, FBW7, Fbw7, Fbwd6, FBX30, Fbx30, FBXO30, Fbxo30, FBXW6, Fbxw6, hAgo, hCdc4, SEL-10, SEL10Bezeichner auf Proteinebene für FBXW7
- F-box and WD-40 domain protein 7
- F-box/WD repeat-containing protein 7
- F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
- F-box protein FBW7
- F-box protein FBX30
- F-box protein SEL-10
- archipelago
- homolog of C elegans sel-10
- F-box and WD-40 domain protein 7, archipelago homolog
- F-box and WD-40 domain-containing protein 7
- F-box protein Fbxw6
- F-box-WD40 repeat protein 6
- f-box only protein 30
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