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FE65 Produkte

(Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Kategorien

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012].

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Ausgewählte FE65 Kategorien

FE65 Antikörper

High quality antibodies with extensive validation data.

FE65 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene FE65 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, IHC (p)
Validierungen
  • (4)
Kat. Nr. ABIN3043784
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IHC
Validierungen
  • (2)
Kat. Nr. ABIN7144040
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Mouse, Rat
Applikation WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro)
Validierungen
  • (2)
Kat. Nr. ABIN725075
Menge 100 μL
Datenblatt Datenblatt

Empfohlene FE65 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1345282
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1345280
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1345278
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren FE65 Produkten

Sun, Sun, Lungchukiet, Quarni, Yang, Zhang, Bai: "Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation." in: Scientific reports, Vol. 5, pp. 11529, (2015) (PubMed).

Guénette, Chang, Hiesberger, Richardson, Eckman, Eckman, Hammer, Herz: "Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development." in: The EMBO journal, Vol. 25, Issue 2, pp. 420-31, (2006) (PubMed).

Hoe, Magill, Guenette, Fu, Vicini, Rebeck: "FE65 interaction with the ApoE receptor ApoEr2." in: The Journal of biological chemistry, Vol. 281, Issue 34, pp. 24521-30, (2006) (PubMed).

Müller, Concannon, Ward, Walsh, Tirniceriu, Tribl, Kögel, Prehn, Egensperger: "Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)." in: Molecular biology of the cell, Vol. 18, Issue 1, pp. 201-10, (2006) (PubMed).

Kinoshita, Shah, Tangredi, Strickland, Hyman: "The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 41182-8, (2003) (PubMed).

Zhao, Lee: "The transcriptional activity of the APP intracellular domain-Fe65 complex is inhibited by activation of the NF-kappaB pathway." in: Biochemistry, Vol. 42, Issue 12, pp. 3627-34, (2003) (PubMed).

Walsh, Fadeeva, LaVoie, Paliga, Eggert, Kimberly, Wasco, Selkoe: "gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins." in: Biochemistry, Vol. 42, Issue 22, pp. 6664-73, (2003) (PubMed).

Cao, Südhof: "A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60." in: Science (New York, N.Y.), Vol. 293, Issue 5527, pp. 115-20, (2001) (PubMed).

Synonyme und alternative Namen zu FE65

amyloid beta precursor protein binding family B member 1 (APBB1), amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog (apbb1.L), amyloid beta (A4) precursor protein-binding, family B, member 1 (Apbb1), amyloid beta precursor protein binding family B member 1 (Apbb1), apbb1, FE65, Fe65, MGC80654, MGC:9072, RIR, Rir

Bezeichner auf Proteinebene für FE65

  • adaptor protein FE65a2
  • amyloid beta A4 precursor protein-binding family B member 1
  • stat-like protein
  • amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
  • amyloid beta A4 precursor protein-binding, family B, member 1
  • amyloid beta precursor protein-binding B1
  • amyloid beta A4 precursor protein-binding family B member 1-like
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