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Fgr Produkte

(Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))

Kategorien

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].

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Ausgewählte Fgr Kategorien

Fgr Antikörper

High quality antibodies with extensive validation data.

Fgr ELISA Kits

Reliable ELISA kits for a wide range of species.

Fgr Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene Fgr Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IHC (p), IF
Validierungen
  • (2)
  • (5)
Kat. Nr. ABIN392096
Menge 400 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC (p)
Validierungen
  • (6)
Kat. Nr. ABIN560883
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IHC, IF
Validierungen
  • (3)
Kat. Nr. ABIN7174020
Menge 100 μg
Datenblatt Datenblatt

Empfohlene Fgr ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN4886105
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN4882882
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6385940
Menge 96 tests
Datenblatt Datenblatt

Empfohlene Fgr Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1354064
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1354066
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (2)
Kat. Nr. ABIN2721125
Menge 20 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren Fgr Produkten

Brian, Jolicoeur, Guerrero, Nunez, Sychev, Hegre, Sætrom, Habib, Drake, Schwertfeger, Freedman: "Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells." in: eLife, Vol. 8, (2020) (PubMed).

Dwyer, Mouchemore, Steer, Sunderland, Sampaio, Greenland, Joyce, Pixley: "Src family kinase expression and subcellular localization in macrophages: implications for their role in CSF-1-induced macrophage migration." in: Journal of leukocyte biology, Vol. 100, Issue 1, pp. 163-75, (2016) (PubMed).

Freedman, Tan, Skrzypczynska, Manz, Sjaastad, Goodridge, Lowell, Weiss: "LynA regulates an inflammation-sensitive signaling checkpoint in macrophages." in: eLife, Vol. 4, (2016) (PubMed).

Henderson, Gonzales, Arora, Choudhary, Trent, Von Hoff, Mousses, Azorsa: "High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells." in: Molecular cancer research : MCR, Vol. 9, Issue 6, pp. 724-32, (2011) (PubMed).

Tatarov, Mitchell, Seywright, Leung, Brunton, Edwards: "SRC family kinase activity is up-regulated in hormone-refractory prostate cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 10, pp. 3540-9, (2009) (PubMed).

Heneghan, Connaghan-Jones, Miura, Bain: "Coactivator assembly at the promoter: efficient recruitment of SRC2 is coupled to cooperative DNA binding by the progesterone receptor." in: Biochemistry, Vol. 46, Issue 39, pp. 11023-32, (2007) (PubMed).

Zhang, Meng, Chu, Takai, Lowell: "The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B." in: Immunity, Vol. 22, Issue 2, pp. 235-46, (2005) (PubMed).

Carriero, Franco, Gargiulo, Vocca, Cito, Fontana, Iaccarino, Del Pozzo, Guardiola, Stoppelli: "Inhibition of receptor-dependent urokinase signaling by specific Ser to Glu substitutions." in: Biological chemistry, Vol. 383, Issue 1, pp. 107-13, (2002) (PubMed).

Cordon-Cardo, Richon: "Expression of the retinoblastoma protein is regulated in normal human tissues." in: The American journal of pathology, Vol. 144, Issue 3, pp. 500-10, (1994) (PubMed).

Dunaief, Strober, Guha, Khavari, Alin, Luban, Begemann, Crabtree, Goff: "The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest." in: Cell, Vol. 79, Issue 1, pp. 119-30, (1994) (PubMed).

Synonyme und alternative Namen zu Fgr

FGR proto-oncogene, Src family tyrosine kinase (FGR), FGR proto-oncogene, Src family tyrosine kinase (Fgr), c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr, SRC2

Bezeichner auf Proteinebene für Fgr

  • Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
  • c-fgr protooncogene
  • c-src-2 proto-oncogene
  • p55-c-fgr protein
  • proto-oncogene c-Fgr
  • proto-oncogene tyrosine-protein kinase FGR
  • tyrosine-protein kinase Fgr
  • v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
  • Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog
  • proto-oncogene tyrosine-protein kinase Fgr
  • tyrosine-protein kinase Fgr-like
  • p55-Fgr
  • feline Gardner-Rasheed sarcoma viral oncogene homolog
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