FIG4 Produkte
(FIG4 Homolog, SAC1 Lipid Phosphatase Domain Containing (FIG4))
Kategorien
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008].
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Ausgewählte FIG4 Kategorien
FIG4 Antikörper
High quality antibodies with extensive validation data.
FIG4 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene FIG4 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p), ICC, IF
Validierungen
- (3)
Kat. Nr.
ABIN2856730
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB
Validierungen
- (2)
Kat. Nr.
ABIN1537627
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (1)
Kat. Nr.
ABIN7181220
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene FIG4 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1354092
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3092551
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3136801
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren FIG4 Produkten
: "Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy." in: Human molecular genetics, Vol. 24, Issue 2, pp. 383-96, (2014) (PubMed).: "Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy." in: Epilepsy research, Vol. 108, Issue 9, pp. 1511-8, (2014) (PubMed).
: "Murine Fig4 is dispensable for muscle development but required for muscle function." in: Skeletal muscle, Vol. 3, Issue 1, pp. 21, (2013) (PubMed).
: "Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B." in: Journal of medicinal chemistry, Vol. 55, Issue 21, pp. 9312-30, (2012) (PubMed).
: "In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 43, pp. 17472-7, (2012) (PubMed).
: "Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J." in: PLoS genetics, Vol. 7, Issue 6, pp. e1002104, (2011) (PubMed).
: "Trauma does not accelerate neuronal degeneration in Fig4 insufficient mice." in: Journal of the neurological sciences, Vol. 312, Issue 1-2, pp. 102-7, (2011) (PubMed).
: "Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies." in: PLoS genetics, Vol. 7, Issue 10, pp. e1002319, (2011) (PubMed).
Synonyme und alternative Namen zu FIG4
FIG4 phosphoinositide 5-phosphatase (Fig4), FIG4 phosphoinositide 5-phosphatase (FIG4), A530089I17Rik, AI326867, ALS11, CMT4J, dJ249I4.1, KIAA0274, Kiaa0274, RGD1311375, Sac3, SAC3, YVSBezeichner auf Proteinebene für FIG4
- SAC domain-containing protein 3
- Sac domain-containing inositol phosphatase 3
- phosphatidylinositol 3,5-bisphosphate 5-phosphatase
- polyphosphoinositide phosphatase
- FIG4 homolog, SAC domain containing lipid phosphatase
- FIG4 homolog, SAC1 domain containing lipid phosphatase
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