FLT3 Produkte
(Fms-Related tyrosine Kinase 3 (FLT3))
Kategorien
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008].
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Ausgewählte FLT3 Kategorien
FLT3 Antikörper
High quality antibodies with extensive validation data.
FLT3 ELISA Kits
Reliable ELISA kits for a wide range of species.
FLT3 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene FLT3 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC
Validierungen
- (2)
- (4)
Kat. Nr.
ABIN1724846
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Mouse, Rat
Applikation
WB, ELISA, IHC (p)
Validierungen
- (6)
Kat. Nr.
ABIN5518988
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC
Validierungen
- (4)
Kat. Nr.
ABIN7012052
Menge
60 μL
Datenblatt
Datenblatt
Empfohlene FLT3 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6955938
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validierungen
- (3)
Kat. Nr.
ABIN6730593
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6966839
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene FLT3 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (5)
Kat. Nr.
ABIN7274657
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Cynomolgus
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7274655
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
HEK-293 Cells
Validierungen
- (2)
Kat. Nr.
ABIN7274660
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren FLT3 Produkten
: "Rationale for a Combination Therapy Consisting of MCL1- and MEK-Inhibitors in Acute Myeloid Leukemia." in: Cancers, Vol. 11, Issue 11, (2019) (PubMed).: "Alpha-1 Antitrypsin Prevents the Development of Preeclampsia Through Suppression of Oxidative Stress." in: Frontiers in physiology, Vol. 7, pp. 176, (2016) (PubMed).
: "A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling." in: Leukemia, Vol. 27, Issue 12, pp. 2301-10, (2013) (PubMed).
: "Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 8, pp. 3822-30, (2012) (PubMed).
: "Influence of FLT3-internal tandem duplication allele burden and white blood cell count on the outcome in patients with intermediate-risk karyotype acute myeloid leukemia." in: Cancer, Vol. 118, Issue 24, pp. 6110-7, (2012) (PubMed).
: "Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia." in: Blood, Vol. 120, Issue 15, pp. 3069-79, (2012) (PubMed).
: "Mesenchymal stem cells originating from ES cells show high telomerase activity and therapeutic benefits." in: Differentiation; research in biological diversity, Vol. 82, Issue 3, pp. 153-64, (2011) (PubMed).
: "Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling." in: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 10918-29, (2011) (PubMed).
: "A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 12, pp. 8126-34, (2008) (PubMed).
: "Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling." in: British journal of haematology, Vol. 141, Issue 4, pp. 483-93, (2008) (PubMed).
Synonyme und alternative Namen zu FLT3
fms related tyrosine kinase 3 (FLT3), FMS-like tyrosine kinase 3 (Flt3), fms-related tyrosine kinase 3 (Flt3), fms related tyrosine kinase 3 (Flt3), B230315G04, CD135, Flk-2, FLK-2, Flk2, FLK2, Flt-3, FLT3, Ly72, STK1, wmflBezeichner auf Proteinebene für FLT3
- fms-related tyrosine kinase 3
- FL cytokine receptor-like
- FL cytokine receptor
- fetal liver kinase 2
- receptor-type tyrosine-protein kinase FLT3
- tyrosine-protein kinase FLT3
- tyrosine-protein kinase receptor flk-2
- CD135 antigen
- STK-1
- fms-like tyrosine kinase 3
- growth factor receptor tyrosine kinase type III
- stem cell tyrosine kinase 1
- FMS-like tyrosine kinase 3
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