FXYD5 Produkte
(FXYD Domain Containing Ion Transport Regulator 5 (FXYD5))
Kategorien
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009].
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Ausgewählte FXYD5 Kategorien
FXYD5 Antikörper
High quality antibodies with extensive validation data.
FXYD5 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene FXYD5 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Saccharomyces cerevisiae
Applikation
WB
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN2780210
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC
Validierungen
- (2)
Kat. Nr.
ABIN7153251
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (2)
Kat. Nr.
ABIN184712
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene FXYD5 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN1098542
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN2129321
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren FXYD5 Produkten
: "Fxyd5 activates the NF‑κB pathway and is involved in chondrocytes inflammation and extracellular matrix degradation." in: Molecular medicine reports, Vol. 25, Issue 4, (2022) (PubMed).: "FXYD5 modulates Na+ absorption and is increased in cystic fibrosis airway epithelia." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 294, Issue 4, pp. L654-64, (2008) (PubMed).
: "Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell-cell adhesion." in: Glycobiology, Vol. 13, Issue 7, pp. 521-7, (2003) (PubMed).
: "Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 1, pp. 365-70, (2002) (PubMed).
Synonyme und alternative Namen zu FXYD5
FXYD domain containing ion transport regulator 5 (FXYD5), FXYD domain-containing ion transport regulator 5 (Fxyd5), DYSAD, EF-8, FXYD5, IWU1, KCT1, OIT2, Oit2, PRO6241, RICBezeichner auf Proteinebene für FXYD5
- FXYD domain-containing ion transport regulator 5
- FXYD domain containing ion transport regulator 5
- dysadherin
- keratinocytes associated transmembrane protein 1
- ion channel homolog RIC
- oncoprotein induced transcript 2
- oncoprotein-induced protein 2
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