GAB2 Produkte
(GRB2-Associated Binding Protein 2 (GAB2))
Kategorien
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009].
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Ausgewählte GAB2 Kategorien
GAB2 Antikörper
High quality antibodies with extensive validation data.
GAB2 ELISA Kits
Reliable ELISA kits for a wide range of species.
GAB2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene GAB2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, IF
Validierungen
- (4)
Kat. Nr.
ABIN7154436
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validierungen
- (4)
Kat. Nr.
ABIN685273
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Rat
Applikation
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validierungen
- (4)
Kat. Nr.
ABIN685288
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene GAB2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380840
Menge
2 x 96 tests
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380841
Menge
2 x 96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6217340
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene GAB2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1354623
Menge
25 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7416967
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3092725
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren GAB2 Produkten
: "K48-Linked Ubiquitination Contributes to Nicotine-Augmented Bone Marrow-Derived Dendritic-Cell-Mediated Adaptive Immunity." in: Vaccines, Vol. 9, Issue 3, (2021) (PubMed).: "PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-κB Inactivation." in: Journal of immunology research, Vol. 2018, pp. 5070573, (2018) (PubMed).
: "Decreased expression of Gab2 in patients with temporal lobe epilepsy and pilocarpine-induced rat model." in: Synapse (New York, N.Y.), Vol. 68, Issue 4, pp. 168-77, (2014) (PubMed).
: "In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 3, pp. 1102-7, (2014) (PubMed).
: "Gab2-mediated signaling promotes melanoma metastasis." in: The American journal of pathology, Vol. 174, Issue 4, pp. 1524-33, (2009) (PubMed).
: "A role for the scaffolding adapter GAB2 in breast cancer." in: Nature medicine, Vol. 12, Issue 1, pp. 114-21, (2006) (PubMed).
: "From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies." in: Molecular & cellular proteomics : MCP, Vol. 5, Issue 6, pp. 1072-81, (2006) (PubMed).
: "Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules." in: The Journal of biological chemistry, Vol. 276, Issue 48, pp. 45175-83, (2001) (PubMed).
Synonyme und alternative Namen zu GAB2
GRB2 associated binding protein 2 (GAB2), GRB2 associated binding protein 2 (gab2), GRB2-associated binding protein 2 (Gab2), growth factor receptor bound protein 2-associated protein 2 (Gab2), AI463667, D130058I17Rik, GAB2, p97Bezeichner auf Proteinebene für GAB2
- GRB2-associated binding protein 2
- GRB2-associated-binding protein 2
- Grb2-associated binder 2
- growth factor receptor bound protein 2-associated protein 2
- pp100
- GRB2-associated binder 2
- Grb2 associated binder 2
- PH domain-containing adaptor molecule p97
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