GAD Produkte
(Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1))
Kategorien
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008].
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Ausgewählte GAD Kategorien
GAD Antikörper
High quality antibodies with extensive validation data.
GAD ELISA Kits
Reliable ELISA kits for a wide range of species.
GAD Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene GAD Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, ICC, IHC (p), IF, IHC (fro), IHC (ff), IHC (wm)
Validierungen
- (7)
Kat. Nr.
ABIN2855214
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF
Validierungen
- (7)
Kat. Nr.
ABIN3017019
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Rat
Applikation
WB, IHC, IP, ICC
Validierungen
- (5)
Kat. Nr.
ABIN7437155
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene GAD ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (5)
Kat. Nr.
ABIN6574313
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6967051
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6967050
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene GAD Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1354667
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7505296
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7401104
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren GAD Produkten
: "A novel homozygous mutation in GAD1 gene described in a schizophrenic patient impairs activity and dimerization of GAD67 enzyme." in: Scientific reports, Vol. 8, Issue 1, pp. 15470, (2018) (PubMed).: "Dietary Restriction Affects Neuronal Response Property and GABA Synthesis in the Primary Visual Cortex." in: PLoS ONE, Vol. 11, Issue 2, pp. e0149004, (2016) (PubMed).
: "Antibodies to inhibitory synaptic proteins in neurological syndromes associated with glutamic acid decarboxylase autoimmunity." in: PLoS ONE, Vol. 10, Issue 3, pp. e0121364, (2015) (PubMed).
: "Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing." in: Frontiers in cellular neuroscience, Vol. 9, pp. 159, (2015) (PubMed).
: "Characterization of continuous B-cell epitopes in the N-terminus of glutamate decarboxylase67 using monoclonal antibodies." in: Journal of peptide science : an official publication of the European Peptide Society, Vol. 20, Issue 12, pp. 928-34, (2014) (PubMed).
: "Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome." in: Neurobiology of disease, Vol. 63, pp. 92-106, (2014) (PubMed).
: "Cellular distribution of the NMDA-receptor activated synapto-nuclear messenger Jacob in the rat brain." in: Brain structure & function, Vol. 219, Issue 3, pp. 843-60, (2014) (PubMed).
: "Interaction of NAP-22 with brain glutamic acid decarboxylase (GAD)." in: Neuroscience letters, Vol. 537, pp. 50-4, (2013) (PubMed).
: "High-fat diets induce changes in hippocampal glutamate metabolism and neurotransmission." in: American journal of physiology. Endocrinology and metabolism, Vol. 302, Issue 4, pp. E396-402, (2012) (PubMed).
: "Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice." in: Neuroscience, Vol. 189, pp. 108-22, (2011) (PubMed).
Synonyme und alternative Namen zu GAD
glutamate decarboxylase 1 (GAD1), glutamate decarboxylase 1 L homeolog (gad1.1.L), glutamate decarboxylase (GAD), glutamate decarboxylase 1 (Gad1), glutamate decarboxylase 1b (gad1b), CPSQ1, cpsq1, EP10, GAD, Gad-1, GAD-67, gad1, GAD1, gad1-A, GAD25, GAD44, gad67, GAD67, Gad67, GLUTAMATE DECARBOXYLASE, glutamate decarboxylase, GLUTAMATE DECARBOXYLASE 1, MKP11.30, MKP11_30, SCPBezeichner auf Proteinebene für GAD
- 67 kDa glutamic acid decarboxylase
- GAD-67
- glutamate decarboxylase 1
- glutamate decarboxylase 67 kDa isoform
- glutamic acid decarboxylase
- glutamate decarboxylase, 67 kDa isoform
- glutamic acid decarboxylase 1
- glutamate decarboxylase 67
- GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE)
- Glutamate decarboxylase 1 (brain)
- glutamate decarboxylase 1 variant GAD67NT
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