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GBA Produkte

(Glucosidase, Beta, Acid (GBA))

Kategorien

This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010].

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Ausgewählte GBA Kategorien

GBA Antikörper

High quality antibodies with extensive validation data.

GBA ELISA Kits

Reliable ELISA kits for a wide range of species.

GBA Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene GBA Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC (p), IF
Validierungen
  • (5)
  • (6)
Kat. Nr. ABIN561009
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC, IP, ICC
Validierungen
  • (7)
Kat. Nr. ABIN7434968
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Mouse, Rat
Applikation IHC, IF
Validierungen
  • (5)
Kat. Nr. ABIN7074062
Menge 100 μL
Datenblatt Datenblatt

Empfohlene GBA ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Mouse
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6967044
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6999571
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6956132
Menge 96 tests
Datenblatt Datenblatt

Empfohlene GBA Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN7123107
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1354865
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1354861
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren GBA Produkten

Bieri, Brahic, Bousset, Couthouis, Kramer, Ma, Nakayama, Monbureau, Defensor, Schüle, Shamloo, Melki, Gitler: "LRRK2 modifies α-syn pathology and spread in mouse models and human neurons." in: Acta neuropathologica, Vol. 137, Issue 6, pp. 961-980, (2019) (PubMed).

Massaro, Mattar, Wong, Sirka, Buckley, Herbert, Karlsson, Perocheau, Burke, Heales, Richard-Londt, Brandner, Huebecker, Priestman, Platt, Mills, Biswas, Cooper, Chan, Cheng, Waddington, Rahim: "Fetal gene therapy for neurodegenerative disease of infants." in: Nature medicine, Vol. 24, Issue 9, pp. 1317-1323, (2018) (PubMed).

Zancan, Bellesso, Costa, Salvalaio, Stroppiano, Hammond, Argenton, Filocamo, Moro: "Glucocerebrosidase deficiency in zebrafish affects primary bone ossification through increased oxidative stress and reduced Wnt/β-catenin signaling." in: Human molecular genetics, Vol. 24, Issue 5, pp. 1280-94, (2015) (PubMed).

Murphy, Gysbers, Abbott, Tayebi, Kim, Sidransky, Cooper, Garner, Halliday: "Reduced glucocerebrosidase is associated with increased ?-synuclein in sporadic Parkinson's disease." in: Brain : a journal of neurology, Vol. 137, Issue Pt 3, pp. 834-48, (2014) (PubMed).

Bendikov-Bar, Rapaport, Larisch, Horowitz: "Parkin-mediated ubiquitination of mutant glucocerebrosidase leads to competition with its substrates PARIS and ARTS." in: Orphanet journal of rare diseases, Vol. 9, pp. 86, (2014) (PubMed).

Shu, Vivekanandan-Giri, Pennathur, Smid, Aerts, Hollak, Shayman: "Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry disease." in: Kidney international, Vol. 86, Issue 1, pp. 58-66, (2014) (PubMed).

Bendikov-Bar, Horowitz: "Gaucher disease paradigm: from ERAD to comorbidity." in: Human mutation, Vol. 33, Issue 10, pp. 1398-407, (2012) (PubMed).

Bendikov-Bar, Ron, Filocamo, Horowitz: "Characterization of the ERAD process of the L444P mutant glucocerebrosidase variant." in: Blood cells, molecules & diseases, Vol. 46, Issue 1, pp. 4-10, (2011) (PubMed).

Campeau, Rafei, Boivin, Sun, Grabowski, Galipeau: "Characterization of Gaucher disease bone marrow mesenchymal stromal cells reveals an altered inflammatory secretome." in: Blood, Vol. 114, Issue 15, pp. 3181-90, (2009) (PubMed).

Synonyme und alternative Namen zu GBA

glucosylceramidase beta (GBA), beta glucosidase 25 (BGLU25), beta-glucosidase (PSPTO_3318), beta-glucosidase (bglX), Beta-glucosidase (bglA4), glucosidase, beta, acid (Gba), glucosylceramidase beta (Gba), glucosylceramidase (LOC100399524), beta-glucosidase (bglA.2), bglX-2 (bglX-2), glucosidase, beta, acid (GBA), BETA-GLUCOSIDASE, betaGC, beta glucosidase 25, GBA1, GC, GCase, GCB, GLUC, PSPTO3318, PSPTO4290, T12J13.8, T12J13_8

Bezeichner auf Proteinebene für GBA

  • D-glucosyl-N-acylsphingosine glucohydrolase
  • acid beta-glucosidase
  • alglucerase
  • beta-glucocerebrosidase
  • glucosylceramidase
  • imiglucerase
  • lysosomal glucocerebrosidase
  • beta-glucosidase
  • Beta-glucosidase
  • acid beta glucosidase
  • glucocerebrosidase
  • glucosidase, beta; acid
  • glucosidase, beta, acid
  • glucosylceramidase-like
  • glucosidase, beta; acid (includes glucosylceramidase)
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