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GRB10 Produkte

(Growth Factor Receptor-Bound Protein 10 (GRB10))

Kategorien

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010].

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Ausgewählte GRB10 Kategorien

GRB10 Antikörper

High quality antibodies with extensive validation data.

GRB10 ELISA Kits

Reliable ELISA kits for a wide range of species.

GRB10 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene GRB10 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC (p), ICC, IHC (fro)
Validierungen
  • (7)
Kat. Nr. ABIN7436048
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA
Validierungen
  • (3)
Kat. Nr. ABIN561124
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC, IF
Validierungen
  • (2)
Kat. Nr. ABIN3184930
Menge 100 μL
Datenblatt Datenblatt

Empfohlene GRB10 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Rat
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6967246
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6956335
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Qualitative Cell ELISA
Validierungen
Kat. Nr. ABIN1380446
Menge 2 x 96 tests
Datenblatt Datenblatt

Empfohlene GRB10 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1355698
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1355696
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7398446
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren GRB10 Produkten

Nantel, Mohammad-Ali, Sherk, Posner, Thomas: "Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases." in: The Journal of biological chemistry, Vol. 273, Issue 17, pp. 10475-84, (1998) (PubMed).

Frantz, Giorgetti-Peraldi, Ottinger, Shoelson: "Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains." in: The Journal of biological chemistry, Vol. 272, Issue 5, pp. 2659-67, (1997) (PubMed).

Dong, Du, Porter, Kolakowski, Lee, Mandarino, Fan, Yee, Liu, Mandarino: "Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma." in: The Journal of biological chemistry, Vol. 272, Issue 46, pp. 29104-12, (1997) (PubMed).

ONeill, Rose, Pillay, Hotta, Olefsky, Gustafson: "Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling." in: The Journal of biological chemistry, Vol. 271, Issue 37, pp. 22506-13, (1996) (PubMed).

Liu, Roth: "Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 22, pp. 10287-91, (1995) (PubMed).

Synonyme und alternative Namen zu GRB10

growth factor receptor bound protein 10 (GRB10), growth factor receptor-bound protein 10a (grb10a), growth factor receptor bound protein 10 (grb10), growth factor receptor bound protein 10 L homeolog (grb10.L), growth factor receptor-bound protein 10 (LOC100434903), growth factor receptor bound protein 10 (Grb10), 5730571D09Rik, AI325020, grb-10, Grb-10, grb-ir, GRB-IR, grb10, GRB10, irbp, IRBP, LOC100224775, meg1, Meg1, MEG1, mKIAA0207, RGD1566234, rss, RSS, zgc:91987

Bezeichner auf Proteinebene für GRB10

  • growth factor receptor-bound protein 10
  • zgc:91987growth factor receptor-bound protein 10
  • growth factor receptor-bound protein 10-like
  • GRB10 adapter protein
  • maternally expressed gene 1 protein
  • GRB10 adaptor protein
  • insulin receptor-binding protein Grb-IR
  • maternally expressed gene 1
  • adapter protein
  • binds to insulin receptor and IGF1R
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