HLA-ABC Produkte
(HLA-ABC)
Kategorien
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008].
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Ausgewählte HLA-ABC Kategorien
HLA-ABC Antikörper
High quality antibodies with extensive validation data.
Empfohlene HLA-ABC Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Baboon, Cat, Cow, Human, Monkey
Applikation
FACS, IP, IHC (fro), WB, IHC
Validierungen
- (2)
Kat. Nr.
ABIN292517
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Cat, Cow, Human, Monkey, Primate
Applikation
FACS, IP, IHC (fro), IF, EIA
Validierungen
- (3)
- (2)
Kat. Nr.
ABIN118900
Menge
0.2 mg
Datenblatt
Datenblatt
Reaktivität
Baboon, Cat, Chimpanzee, Cow, Human, Macaque, Monkey, Primate
Applikation
FACS, IP, IHC (fro), IF, Func, EIA, DNA Mic
Validierungen
- (4)
- (2)
Kat. Nr.
ABIN118899
Menge
0.5 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren HLA-ABC Produkten
: "Strong Replication Interference Between Hepatitis Delta Viruses in Human Liver Chimeric Mice." in: Frontiers in microbiology, Vol. 12, pp. 671466, (2021) (PubMed).: "Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Formation in Bilayer Engineered Skin Substitutes." in: Cell transplantation, Vol. 28, Issue 9-10, pp. 1242-1256, (2020) (PubMed).
: "Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo. ..." in: Neuron, (2019) (PubMed).
: "Human embryonic stem cell derived-mesenchymal stem cells: an alternative mesenchymal stem cell source for regenerative medicine therapy." in: Regenerative medicine, Vol. 9, Issue 4, pp. 453-65, (2014) (PubMed).
: "Heterelogous expression of mutated HLA-G decreases immunogenicity of human embryonic stem cells and their epidermal derivatives." in: Stem cell research, Vol. 13, Issue 2, pp. 342-54, (2014) (PubMed).
: "HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 5, pp. 2990-7, (2011) (PubMed).
: "The Epstein-Barr virus-encoded BILF1 protein modulates immune recognition of endogenously processed antigen by targeting major histocompatibility complex class I molecules trafficking on both the ..." in: Journal of virology, Vol. 85, Issue 4, pp. 1604-14, (2011) (PubMed).
: "Viral inhibition assay: a CD8 T cell neutralization assay for use in clinical trials of HIV-1 vaccine candidates." in: The Journal of infectious diseases, Vol. 201, Issue 5, pp. 720-9, (2010) (PubMed).
: "The nature of peptides presented by an HLA class I low expression allele." in: Haematologica, Vol. 95, Issue 8, pp. 1373-80, (2010) (PubMed).
: "WT1 peptide vaccination in combination with imatinib therapy for a patient with CML in the chronic phase." in: International journal of medical sciences, Vol. 7, Issue 2, pp. 72-81, (2010) (PubMed).
Synonyme und alternative Namen zu HLA-ABC
major histocompatibility complex, class I, A (HLA-A), HLAABezeichner auf Proteinebene für HLA-ABC
- HLA class I histocompatibility antigen, A-1 alpha chain
- MHC class I antigen HLA-A heavy chain
- antigen presenting molecule
- leukocyte antigen class I-A
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