HMGCR Produkte
(3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
Kategorien
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
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Ausgewählte HMGCR Kategorien
HMGCR Antikörper
High quality antibodies with extensive validation data.
HMGCR ELISA Kits
Reliable ELISA kits for a wide range of species.
HMGCR Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene HMGCR Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF
Validierungen
- (2)
- (9)
Kat. Nr.
ABIN3022294
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Rat
Applikation
WB, IHC, IP, ICC
Validierungen
- (7)
Kat. Nr.
ABIN7435559
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p)
Validierungen
- (2)
- (3)
Kat. Nr.
ABIN753283
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene HMGCR ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (2)
- (1)
Kat. Nr.
ABIN6953355
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6964469
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6964468
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene HMGCR Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7121607
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1306814
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Rat
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7397588
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren HMGCR Produkten
: "Fluvastatin is effective against thymic carcinoma." in: Life sciences, Vol. 240, pp. 117110, (2020) (PubMed).: "Transthyretin Regulated by linc00657/miR-205-5p Promoted Cholesterol Metabolism by Inducing SREBP2-HMGCR and Inhibiting LXRα-CYP7A1." in: Archives of medical research, Vol. 51, Issue 4, pp. 317-326, (2020) (PubMed).
: "MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice." in: Cell death & disease, Vol. 8, Issue 7, pp. e2916, (2018) (PubMed).
: "27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells." in: Neurotoxicology, Vol. 59, pp. 88-97, (2017) (PubMed).
: "Hempseed Peptides Exert Hypocholesterolemic Effects with a Statin-Like Mechanism." in: Journal of agricultural and food chemistry, Vol. 65, Issue 40, pp. 8829-8838, (2017) (PubMed).
: "Effects of sepsis on the metabolism of sphingomyelin and cholesterol in mice with liver dysfunction." in: Experimental and therapeutic medicine, Vol. 14, Issue 6, pp. 5635-5640, (2017) (PubMed).
: "Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice." in: Journal of molecular and cellular cardiology, Vol. 99, pp. 35-46, (2016) (PubMed).
: "Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK)." in: BMC complementary and alternative medicine, Vol. 16, pp. 51, (2016) (PubMed).
: "Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice." in: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 36, Issue 5, pp. 683-690, (2016) (PubMed).
: "Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters." in: Life sciences, Vol. 151, pp. 50-60, (2016) (PubMed).
Synonyme und alternative Namen zu HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog (hmgcr.L), 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr), HMG Coenzyme A reductase (Hmgcr), 3-hydroxy-3-methylglutaryl-CoA reductase b (hmgcrb), 3H3M, BcDNA:LD15354, bro1, bs32f05.y1, CG10367, Clb, clb, Dmel\\CG10367, DmHMG-CoAr, Hmg, hmg-coa-r, HMG-CoAR, HmG-CoAR, hmgc, HMGCoAR, HMGCoAr, HMGCoARr, HMGCR, hmgcr, hmgcr2, HMGCR_Dm, HMGR, hmgrc, im:6912716, l(3)01152, l(3)04684, LDLCQ3, Red, zgc:110746Bezeichner auf Proteinebene für HMGCR
- 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
- 3-hydroxy-3-methylglutaryl coenzyme A reductase/HMG-CoA reductase
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
- HMG-CoA reductase
- hydroxymethylglutaryl-CoA reductase
- 3-hydroxy-3-methylglutaryl CoA reductase
- 3-hydroxy-3-methylglutaryl-CoA reductase
- 3-Hydroxy-3-Methylglutaryl CoA reductase
- 3-hydroxy-3-methylglutaryl coenzyme A reductase
- CG10367-PA
- HMG coenzyme A reductase
- HMGCo-A reductase
- HMGCoA reductase
- Hmg-CoA-reductase
- Hmgcr-PA
- columbus
- lethal (3) 04684
- 3-alpha-hydroxy-3-methylglutaryl-CoA reductase
- 3-hydroxy-3-methylglutaryl-CoA reductase b
- 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b
- hmgcr1b
- hmgrb
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