IDE Produkte
(Insulin-Degrading Enzyme (IDE))
Kategorien
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].
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Ausgewählte IDE Kategorien
IDE Antikörper
High quality antibodies with extensive validation data.
IDE ELISA Kits
Reliable ELISA kits for a wide range of species.
IDE Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene IDE Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validierungen
- (6)
- (2)
Kat. Nr.
ABIN723680
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (8)
Kat. Nr.
ABIN7434305
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB, ELISA, IHC (p), IHC (fro)
Validierungen
- (1)
Kat. Nr.
ABIN723665
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene IDE ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN1570456
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Competition ELISA
Validierungen
Kat. Nr.
ABIN626493
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Competition ELISA
Validierungen
Kat. Nr.
ABIN627221
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene IDE Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1307363
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1307365
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN2723516
Menge
20 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren IDE Produkten
: "Protein-Bound Anthocyanin Compounds of Purple Sweet Potato Ameliorate Hyperglycemia by Regulating Hepatic Glucose Metabolism in High-Fat Diet/Streptozotocin-Induced Diabetic Mice." in: Journal of agricultural and food chemistry, Vol. 68, Issue 6, pp. 1596-1608, (2020) (PubMed).: "Neuroprotective effect of ipriflavone against scopolamine-induced memory impairment in rats." in: Psychopharmacology, Vol. 234, Issue 20, pp. 3037-3053, (2018) (PubMed).
: "Thymoquinone-rich fraction nanoemulsion (TQRFNE) decreases Aβ40 and Aβ42 levels by modulating APP processing, up-regulating IDE and LRP1, and down-regulating BACE1 and RAGE in response to high ..." in: Biomedicine & pharmacotherapy, Vol. 95, pp. 780-788, (2018) (PubMed).
: "The Protective Effects of IGF-I against β-Amyloid-related Downregulation of Hippocampal Somatostatinergic System Involve Activation of Akt and Protein Kinase A." in: Neuroscience, Vol. 374, pp. 104-118, (2018) (PubMed).
: "Reduction in Aβ-induced cell death in the hippocampus of 17β-estradiol-treated female rats is associated with an increase in IGF-I signaling and somatostatinergic tone." in: Journal of neurochemistry, Vol. 135, Issue 6, pp. 1257-71, (2016) (PubMed).
: "Vitamin D3 intake as regulator of insulin degrading enzyme and insulin receptor phosphorylation in diabetic rats." in: Biomedicine & pharmacotherapy, Vol. 85, pp. 155-159, (2016) (PubMed).
: "Analysis of the proteolysis of bioactive peptides using a peptidomics approach." in: Nature protocols, Vol. 8, Issue 9, pp. 1730-42, (2013) (PubMed).
: "Promoting scientific standards in Germany." in: Science (New York, N.Y.), Vol. 328, Issue 5976, pp. 307, (2010) (PubMed).
: "Complex formation between metabolic enzymes in tumor cells: unfolding the MDR1-IDE paradigm." in: Molecular cancer therapeutics, Vol. 8, Issue 11, pp. 3171, (2009) (PubMed).
: "Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families." in: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 7825-32, (2007) (PubMed).
Synonyme und alternative Namen zu IDE
insulin degrading enzyme (IDE), insulin-degrading enzyme (ide), insulin-degrading enzyme (LOC591315), insulin-degrading enzyme (CC1G_01115), insulin-degrading enzyme (Bm1_26615), insulin-degrading enzyme (PTRG_10875), metallopeptidase (SJAG_01430), insulin-degrading enzyme (EBI_21700), insulin-degrading enzyme (VDBG_06702), insulin-degrading enzyme (LOAG_08082), insulin-degrading enzyme (PGTG_04982), insulin-degrading enzyme (Tsp_00424), insulin degrading enzyme (Ide), 1300012G03Rik, 4833415K22Rik, AA675336, AI507533, IDE, INSDEGM, INSULYSIN, zgc:162603Bezeichner auf Proteinebene für IDE
- insulysin
- insulin-degrading enzyme
- insulin-degrading enzyme-like
- insulin protease
- insulinase
- Abeta-degrading protease
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