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INPP5D Produkte

(Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

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Ausgewählte INPP5D Kategorien

INPP5D Antikörper

High quality antibodies with extensive validation data.

INPP5D ELISA Kits

Reliable ELISA kits for a wide range of species.

INPP5D Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene INPP5D Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
anti-INPP5D Antikörper (AA 959-1188)
Reaktivität Human
Applikation WB, IHC, IF
Validierungen
  • (5)
Kat. Nr. ABIN6213625
Menge 100 μL
Datenblatt Datenblatt
Rekombinanter anti-INPP5D Antikörper
Reaktivität Human
Applikation WB, ELISA, IHC, IP
Validierungen
  • (3)
Kat. Nr. ABIN7127806
Menge 100 μL
Datenblatt Datenblatt
anti-INPP5D Antikörper (C-Term)
Reaktivität Human, Mouse, Rat
Applikation WB, ELISA, IF, ICC
Validierungen
  • (3)
Kat. Nr. ABIN6265066
Menge 100 μL
Datenblatt Datenblatt

Empfohlene INPP5D ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
INPP5D ELISA Kit
Reaktivität Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validierungen
  • (3)
Kat. Nr. ABIN4889790
Menge 96 tests
Datenblatt Datenblatt
INPP5D ELISA Kit
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6956751
Menge 96 tests
Datenblatt Datenblatt
INPP5D ELISA Kit
Reaktivität Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validierungen
  • (2)
Kat. Nr. ABIN4889791
Menge 96 tests
Datenblatt Datenblatt

Empfohlene INPP5D Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
INPP5D Protein (AA 1-1189) (Strep Tag)
Reaktivität Human
Source Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr. ABIN3095410
Menge 1 mg
Datenblatt Datenblatt
INPP5D Protein (AA 1-1191) (Strep Tag)
Reaktivität Mouse
Source Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr. ABIN3137223
Menge 1 mg
Datenblatt Datenblatt
INPP5D Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (1)
Kat. Nr. ABIN2723485
Menge 20 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren INPP5D Produkten

Tu, Liu, Dong, Yu, Wang, Chen: "Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1: a meaningful and independent marker to predict stroke in the Chinese population." in: Journal of molecular neuroscience : MN, Vol. 52, Issue 4, pp. 507-14, (2014) (PubMed).

Sácha, Zámecník, Barinka, Hlouchová, Vícha, Mlcochová, Hilgert, Eckschlager, Konvalinka: "Expression of glutamate carboxypeptidase II in human brain." in: Neuroscience, Vol. 144, Issue 4, pp. 1361-72, (2007) (PubMed).

Rovenská, Hlouchová, Sácha, Mlcochová, Horák, Zámecník, Barinka, Konvalinka: "Tissue expression and enzymologic characterization of human prostate specific membrane antigen and its rat and pig orthologs." in: The Prostate, Vol. 68, Issue 2, pp. 171-82, (2007) (PubMed).

Mesters, Barinka, Li, Tsukamoto, Majer, Slusher, Konvalinka, Hilgenfeld: "Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer." in: The EMBO journal, Vol. 25, Issue 6, pp. 1375-84, (2006) (PubMed).

Rotblat, Yizhar, Haklai, Ashery, Kloog: "Ras and its signals diffuse through the cell on randomly moving nanoparticles." in: Cancer research, Vol. 66, Issue 4, pp. 1974-81, (2006) (PubMed).

Roy, Plowman, Rotblat, Prior, Muncke, Grainger, Parton, Henis, Kloog, Hancock: "Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling." in: Molecular and cellular biology, Vol. 25, Issue 15, pp. 6722-33, (2005) (PubMed).

Maxwell, Yuan, Anderson, Hibbs, Salem, Jackson: "SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets." in: The Journal of biological chemistry, Vol. 279, Issue 31, pp. 32196-204, (2004) (PubMed).

Rotblat, Prior, Muncke, Parton, Kloog, Henis, Hancock: "Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane." in: Molecular and cellular biology, Vol. 24, Issue 15, pp. 6799-810, (2004) (PubMed).

Giuriato, Pesesse, Bodin, Sasaki, Viala, Marion, Penninger, Schurmans, Erneux, Payrastre: "SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels." in: The Biochemical journal, Vol. 376, Issue Pt 1, pp. 199-207, (2003) (PubMed).

Jiang, Stuible, Chalandon, Li, Chan, Eisterer, Krystal, Eaves, Eaves: "Evidence for a positive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia." in: Blood, Vol. 102, Issue 8, pp. 2976-84, (2003) (PubMed).

Synonyme und alternative Namen zu INPP5D

inositol polyphosphate-5-phosphatase D (INPP5D), phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (LOC100446045), inositol polyphosphate-5-phosphatase D (inpp5d), inositol polyphosphate 5-phosphatase (EHI_159880), inositol polyphosphate 5-phosphatase (EHI_153490), inositol polyphosphate-5-phosphatase D L homeolog (inpp5d.L), phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (LOC100380693), inositol polyphosphate-5-phosphatase D (Inpp5d), 13.t00027, 256.t00004, AI323613, hp51CN, INPP5D, s-SHIP, ship, SHIP, SHIP-1, ship1, SHIP1, SIP-145

Bezeichner auf Proteinebene für INPP5D

  • inositol polyphosphate-5-phosphatase, 145kDa
  • SH2 containing inositol phosphatase
  • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
  • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1-like
  • SH2 domain-containing inositol 5'-phosphatase 1
  • SH2 domain-containing inositol phosphatase 1
  • SH2 domain-containing inositol-5'-phosphatase 1
  • SHIP-1
  • phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
  • Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
  • SH2 containing inositol phosphotase
  • SH2-containing inositol phosphatase SHIP
  • SIP-145
  • Src homology 2 domain-containing inositol-5-phosphatase
  • inositol polyphosphate-5-phosphatase of 145 kDa
  • inositol polyphosphate-5-phosphatase, 145 kDa
  • p150Ship
  • Inositol polyphosphate-5-phosphatase 145 kDa
  • Inositol polyphosphate-5-phosphatase, 145 kDa
  • signaling inositol polyphosphate 5 phosphatase SIP-145

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