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Geldanamycin

Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Produktnummer ABIN1027731
  • Applikation
    Inhibition (Inh)
    Verwendungszweck
    Hsp90 inhibitor
    Spezifität
    Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases. It induces the inactivation, destabilization and eventual degradation of HIF-1alpha. This is specifically a novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for Hsp90 inhibitors. May also be used for detection of cell surface Hsp90. Other geldanamycin fluorophores (BODPY) have been reported and used in FP HTS assays.
    Produktmerkmale
    Hsp90 inhibitor.
    Aufreinigung
    Produced by fermentation
    Reinheit
    >95 %
    Chemical Name
    (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
    Formel
    C29H40N2O9
    Löslichkeit
    Slightly soluble in methanol, chloroform or DMSO (10 mg/ml); insoluble in water
  • Kommentare

    Source: Produced by fermentation.
    Appearance: Yellow Solid

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Solid
    Vorsichtsmaßnahmen
    Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects
    Handhabung
    Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects
    Lagerung
    -20 °C
  • Cha, St Louis, Tradewell, Gentil, Minotti, Jaffer, Chen, Rubenstein, Durham: "A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo." in: Cell stress & chaperones, Vol. 19, Issue 3, pp. 421-35, (2014) (PubMed).

    Mori, Hitora, Nakamura, Yamagami, Horie, Nishimura, Yamamoto: "Hsp90 inhibitor induces autophagy and apoptosis in osteosarcoma cells." in: International journal of oncology, Vol. 46, Issue 1, pp. 47-54, (2014) (PubMed).

  • Molekulargewicht
    560.6
    CAS-Nummer
    30562-34-6
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