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5-Azacytidine

Name: 5-Azacytidine
Brand: antibodies-online
SKU: ABIN7233228
Price: 75.38 EUR
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Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

1 image

Produktnummer ABIN7233228

Datenblatt (PDF)

Applikation

Inhibition (Inh)

Verwendungszweck

DNA hypomethylation agent

Produktmerkmale

Specific inhibitor of DNA methyltransferase. Incorporates into DNA and covalently reacts with and inhibits DNA methyltransferases. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Induces cardiac differentiation of human mesenchymal stem cells by activating ERK. Induces apoptosis in multiple myeloma cells via ATR-mediated DNA double strand breaks. Cell permeable.

Reinheit

>98 %

Chemical Name

4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Formel

C8H12N4O5

Permeabilität

Cell-permeable

Löslichkeit

Soluble in DMSO (up to 25 mg/ml), or in Water (up to 12 mg/ml).
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Radicicol
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Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Powder

Vorsichtsmaßnahmen

GHS – Classification
Acute toxicity, Oral (Category 4), H302
Germ cell mutagenicity (Category 2), H341
Carcinogenicity (Category 1A), H350
Reproductive toxicity (Category 1B), H360
Specific target organ toxicity - repeated exposure (Category 1), H372
Long-term (chronic) aquatic hazard (Category 1), H410

Lagerung

-20 °C
Hintergrund

Ladakamycin, U-18496, NSC-102816, AzaC,Epigenetics,Chromatin,DNA methyltransferase,Stem cells,Cell death,Infectious disease,Apoptosis inducer,DNA damage

Molekulargewicht

244.2

CAS-Nummer

320-67-2