-
- Applikation
- Inhibition (Inh)
- Verwendungszweck
- HAT Inhibitor
- Produktmerkmale
- Anacardic acids occur in cashew nut shells and are similar in structure to urushiols, the irritating components of poison ivy. Anacardic acid inhibits histone acetyltransferases (HATs) p300 (IC50 = 8.5 μM) and PCAF (IC50 = 5.0 μM) with no effect on HDACs. It also suppresses expression or activity of proteins involved in invasion and angiogenesis, e.g. MMP-2 (IC50 = 11 μM) and -9. 6-PDSA, a saturated form of anacardic acid, induces macrophage activation via MAPK and NF-κB. When used at 125 μM, it sensitized cancer cells to radiation therapy by reducing histone expression. It also blocks inducible and constitutive activation of NF-κB in leukemia cells.
- Reinheit
- >98 %
- Chemical Name
- 2-Hydroxy-6-pentadecylbenzoic acid
- Formel
- C22H36O3
- Löslichkeit
- Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (15 mg/ml)
-
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
ResveratrolAct 501-36-0 3,4',5-Trihydroxy-trans-stilbene
PanobinostatInh 404950-80-7 (E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide
HPA (Hexyl-4-pentynoic acid)Inh Cell-permeable 96017-59-3 2-(2-Propynyl)octanoic acid (racemic)
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
DaminozideInh 1596-84-5 1-(2,2-Dimethylhydrazide)butanedioic acid
-
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Powder
- Lagerung
- -20 °C
-
- Hintergrund
- 6-Pentadecylsalicylic acid, 6-PDSA,Cell adhesion,Epigenetics,Posttranslational modification,Cytokine,MAPK,Acetyltransferase,Protease,Immunology,Angiogenesis,Stem cells,Inflammation,Cancer,NFkappaB,Chromatin
- Molekulargewicht
- 348.5
- CAS-Nummer
- 16611-84-0
-
Sie sind hier:
