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Inh Cell-permeable 550-24-3 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione

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Produktnummer ABIN7233250

Datenblatt (PDF)

Applikation

Inhibition (Inh)

Verwendungszweck

XIAP inhibitor, Apoptosis inducer

Produktmerkmale

Inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 μM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged. Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells. Possesses anti-inflammatory and analgesic activity in vivo. Cell-permeable.

Reinheit

>98 %

Chemical Name

2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione

Formel

C17H26O4

Permeabilität

Cell-permeable

Löslichkeit

Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 3 mg/ml with warming)
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Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

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Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

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Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Powder

Lagerung

-20 °C
Hintergrund

Epigenetics,Posttranslational modification,Acetyltransferase,Cell death,Inflammation,Cancer,Chromatin,Apoptosis inducer

Molekulargewicht

294.39

CAS-Nummer

550-24-3