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GSK-J1

Inh Not-permeable 1373422-53-7 N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine
Produktnummer ABIN7233258

Kurzübersicht für GSK-J1 (ABIN7233258)

Applikation

Inhibition (Inh)

Chemical Name

N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine

Permeabilität

Not-permeable
  • Verwendungszweck

    JMJ H3K27 Demethylase inhibitor (cell impermeable)

    Produktmerkmale

    Potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available.

    Reinheit

    >98 %

    Formel

    C22H23N5O2

    Löslichkeit

    Soluble in DMSO (up to 20 mg/ml).
  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Powder

    Lagerung

    RT
  • Hintergrund

    Epigenetics,Protein demethylase,Posttranslational modification,Chromatin

    Molekulargewicht

    389.46

    CAS-Nummer

    1373422-53-7
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