GSK-J1
Kurzübersicht für GSK-J1 (ABIN7233258)
Applikation
Chemical Name
Permeabilität
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Verwendungszweck
- JMJ H3K27 Demethylase inhibitor (cell impermeable)
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Produktmerkmale
- Potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available.
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Reinheit
- >98 %
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Formel
- C22H23N5O2
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Löslichkeit
- Soluble in DMSO (up to 20 mg/ml).
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Powder
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Lagerung
- RT
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Hintergrund
- Epigenetics,Protein demethylase,Posttranslational modification,Chromatin
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Molekulargewicht
- 389.46
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CAS-Nummer
- 1373422-53-7
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