Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

I-BET762

Inh 1260907-17-2 (4S)- 6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide
Produktnummer ABIN7233261
  • Applikation
    Inhibition (Inh)
    Verwendungszweck
    BET Bromodomain inhibitor, Suppresses Myc transcription
    Produktmerkmale
    I-BET762 is a potent inhibitor of the BET family of bromodomains with no activity at bromodomains BAZ2B, SP140, ATAD2, CREBBO, and PCAF. IC50's for H4Ac peptide displacement: BRD2 = 32.5nM, BRD3 = 42.4nM, BRD4 = 36.1nM. It was able to suppress proinflammatory proteins by macrophage, block acute inflammation in mice, and suppressed the inflammatory function of T cells. Inhibition of BET bromodomains results in downregulation of Myc transcription, an important oncogene.
    Reinheit
    >98 %
    Chemical Name
    (4S)- 6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide
    Formel
    C22H22ClN5O2
    Löslichkeit
    Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Powder
    Vorsichtsmaßnahmen
    GHS – Classification
    Not a hazardous substance or mixture
    Lagerung
    -20 °C
  • Hintergrund
    GSK525762,Epigenetics,Bromodomain,Immunology,Inflammation,Cancer,Posttranslational modification,Chromatin
    Molekulargewicht
    423.90
    CAS-Nummer
    1260907-17-2
Sie sind hier:
Kundenservice