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JIB-04

Inh Cell-permeable 199596-05-9 (E)-5-Chloro-2-(2-(phenyl(pyridine-2-yl)methylene)hydrazinyl)pyridine
Produktnummer ABIN7233263
  • Applikation
    Inhibition (Inh)
    Verwendungszweck
    pan-JUMONJI histone demethylase inhibitor
    Produktmerkmale
    A novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively. Reduces tumor burden and prolongs life in a mouse model. Suppresses translation initiation and enhances mTOR inhibitor sensitivity. Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.
    Reinheit
    >98 %
    Chemical Name
    (E)-5-Chloro-2-(2-(phenyl(pyridine-2-yl)methylene)hydrazinyl)pyridine
    Formel
    C17H13ClN4
    Permeabilität
    Cell-permeable
    Löslichkeit
    Soluble in DMSO (up to 30 mg/ml).
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Powder
    Lagerung
    -20 °C
  • Hintergrund
    Epigenetics,Posttranslational modification,Protein demethylase,Cancer,mTOR,Chromatin
    Molekulargewicht
    308.76
    CAS-Nummer
    199596-05-9
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