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JQ1 (+)

Inh 1268524-70-4 (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
Produktnummer ABIN7233264
  • Applikation
    Inhibition (Inh)
    Verwendungszweck
    Bromodomain inhibitor
    Produktmerkmale
    JQ1 (+) is a potent BET bromodomain inhibitor and is the active isomer. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively (data for + isomer). Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models. Induces squamous differentiation in NMC cell lines and inhibits tumor growth in NMC xenografts. Displays reversible contraceptive effects in male mice. Blocks inflammation and bone loss in periodontitis. Reverses CAR T cell extinction.
    Reinheit
    >98 %
    Chemical Name
    (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
    Formel
    C23H25ClN4O2S
    Löslichkeit
    Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 46 mg/ml)
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Powder
    Vorsichtsmaßnahmen
    GHS – Classification
    Not a hazardous substance or mixture
    Lagerung
    RT
  • Hintergrund
    Epigenetics,Proliferation,Bromodomain,Inflammation,Cancer,Posttranslational modification,Chromatin
    Molekulargewicht
    457.0
    CAS-Nummer
    1268524-70-4
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